|Application ||FC, E, IP|
|Purification||Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant.|
|Shelf Life||18 months from date of despatch.|
|Target/Specificity||Mouse anti-Sheep CD41/CD61 antibody, clone CO.35E4 recognizes ruminant CD41/CD61, also known as GpIIb/IIIa. CD41/CD61 is a calcium-complex dependent heterodimer and is expressed almost exclusively on platelets and on their precursors, the megakaryocytes. This complex is an activation-dependent receptor for RGD (Arg-Gly-Asp)-containing glycoproteins such as fibrinogen, fibronectin, von Willebrand factor, thrombospondin and vitronectin. It plays a central role in platelet aggregation and haemostasis.|
|Preservative & Stabilisers||0.09% Sodium Azide|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Sheep CD41/CD61 Antibody, clone CO.35E4 is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
1. Brodersen, R. et al. (1998) Analysis of the immunological cross reactivities of 213 well characterized monoclonal antibodies with specificities against various leucocyte surface antigens of human and 11 animal species: Vet. Immunol. Immunopathol. 64: 1-13. 2. Pintado, C. O. et al. (1995) Characterisation of a membrane receptor on ruminants and equine platelets and peripheral blood leucocytes similar to the human integrin receptor glycoprotein IIb/IIIa (CD41/CD61). Vet Immunol. Immunopathol. 44 (3-4): 359 - 368. 3. Lalko, C. et al. (2003) Equine platelet CD62P (P-selectin) expression: a phenotypic and morphologic study. Vet. Immunol. Immunopathol. 91: 119 - 134. 4. Major, T.C. et al. (2010) The attenuation of platelet and monocyte activation in a rabbit model of extracorporeal circulation by a nitric oxide releasing polymer.Biomaterials. 31: 2736-45. 5. Brainard, B.M. et al. (2012) Treatment with aspirin or clopidogrel does not affect equine platelet expression of P selectin or platelet-neutrophil aggregates.Vet Immunol Immunopathol. 149: 119-25.
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