Register or Login
  • All
  • Uniprot Id
  • Catalog #
  • Peptide Sequence
>   home   >   Products   >   Primary Antibodies   >   Antibody Collections   >   GPCR Antibodies   >   Anti-Human Thyroid Stimulating Hormone Receptor Antibody, clone 2C11    

Anti-Human Thyroid Stimulating Hormone Receptor Antibody, clone 2C11

Mouse Anti-Human Monoclonal Antibody

Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P16473
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype IgG1
Clone Names 2C11
Calculated MW 86830 Da
Additional Information
Purification Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
Immunogen Recombinant Human TSH receptor.
Shelf Life 18 months from date of despatch.
Gene ID 7253
Other Names Thyrotropin receptor, Thyroid-stimulating hormone receptor, TSH-R, TSHR, LGR3
Target/Specificity Mouse anti-Human thyroid stimulating hormone receptor antibody, clone 2C11 recognizes the human thyroid stimulating hormone receptor (TSHR) otherwise known as the thyrotropin receptor. TSHR is an important molecule in controlling the growth and function of the normal thyroid.Mouse anti-Human thyroid stimulating receptor antibody recognises both native and denatured TSH receptor (binding to an epitope at the carboxy terminus between amino acids 354 and 359). It does inhibit binding of TSH. No cross reactivity has been observed with related LH and FSH receptors.Clone 2C11 recognises the mutant TSH receptor known as I167N as well as the wild type molecule (Costagliolaet al.1998)
Preservative & Stabilisers 0.09% Sodium Azide
Storage Store at +4℃ or at -20 ℃.
PrecautionsAnti-Human Thyroid Stimulating Hormone Receptor Antibody, clone 2C11 is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
Citations (0)

Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.

Submit your citation using an Abgent antibody to, and receive a free "I Love Antibodies" mug.


1. Shepherd PS et al. (1999) Identification of an important thyrotrophin binding site on the human thyrotrophin receptor using monoclonal antibodies.
Mol Cell Endocrinol. 149 (1-2): 197-206. 2. Costagliola, S. et al. (1998) Genetic immunization against the human thyrotropin receptor causes thyroiditis and allows production of monoclonal antibodies recognizing the native receptor.
J Immunol. 160 (3): 1458-65. 3. Haas, A.K. et al. (2011) Mutations that silence constitutive signaling activity in the allosteric ligand-binding site of the thyrotropin receptor.
Cell Mol Life Sci. 68: 159-167. 4. Frenzel, R. et al. (2006) The human thyrotropin receptor is predominantly internalized by beta-arrestin 2.
Endocrinology. 147: 3114-22. 5. Akeno, N. et al. (2011) IFN-{alpha} Mediates the Development of Autoimmunity both by Direct TissueToxicity and through Immune Cell Recruitment Mechanisms.
J Immunol. 186: 4693-706. 6. Akamizu, T. et al. (1999) Characterization of recombinant monoclonal antithyrotropin receptor antibodies (TSHRAbs) derived from lymphocytes of patients with Graves' disease: epitope and binding study of two stimulatory TSHRAbs.
Endocrinology. 140: 1594-601. 7. Chazenbalk, G.D. et al. (2004) Does thyrotropin cleave its cognate receptor?
Endocrinology. 145: 4-10. 8. Chen, C.R. et al. (2003) Targeted restoration of cleavage in a noncleaving thyrotropin receptor demonstrates that cleavage is insufficient to enhance ligand-independent activity.
Endocrinology. 144: 1324-30. 9. Ellerhorst, J.A. et al. (2006) Human melanoma cells express functional receptors for thyroid-stimulating hormone.
Endocr Relat Cancer. 13: 1269-77. 10. Li, Y.S. et al. (2004) Transgenic mice producing major histocompatibility complex class II molecules on thyroid cells do not develop apparent autoimmune thyroid diseases.
Endocrinology. 145: 2524-30. 11. Neumann, S. et al. (2011) A new small-molecule antagonist inhibits Graves' disease antibody activation of the TSH receptor.
J Clin Endocrinol Metab. 96: 548-54. 12. Narumi S et al. (2011) Nonclassic TSH resistance: TSHR mutation carriers with discrepantly high thyroidal iodine uptake.
J Clin Endocrinol Metab. 96 (8): E1340-5. 13. Allen, M.D. et al. (2011) Occupancy of both sites on the thyrotropin (TSH) receptor dimer is necessary for phosphoinositide signaling.
FASEB J. 25: 3687-94.

Abgent welcomes feedback from its customers.

If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.

If you have any additional inquiries please email technical services at

Cat# ABD11563
Availability: Inquire
Bulk Size
Seasonal Special on Bulk Order
Request Quote Here

Ordering Information

United States
AlbaniaAustraliaAustriaBelgiumBosnia & HerzegovinaBrazilBulgariaCanadaCentral AmericaChinaCroatiaCyprusCzech RepublicDenmarkEstoniaFinlandFranceGermanyGreeceHong KongHungaryIcelandIndiaIndonesiaIrelandIsraelItalyJapanLatviaLithuaniaLuxembourgMacedoniaMalaysiaMaltaNetherlandsNew ZealandNorwayPakistanPolandPortugalRomaniaSerbiaSingaporeSlovakiaSloveniaSouth AfricaSouth KoreaSpainSwedenSwitzerlandTaiwanTurkeyUnited KingdomUnited StatesVietnamWorldwideOthers
Abgent, Inc.
(888) 735-7227 / (858) 622-0099
(858) 622-0609
USA Headquarters
(888) 735-7227 / (858) 622-0099 or (858) 875-1900

Shipping Information

Domestic orders (in stock items)
Shipped out the same day. Orders placed after 1 PM (PST) will ship out the next business day.
International orders
Contact your local distributors
Terms & Conditions