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>   home   >   Products   >   Primary Antibodies   >   Anti-Human CD60 Antibody, clone M-T6004    

Anti-Human CD60 Antibody, clone M-T6004

Mouse Anti-Human Monoclonal Antibody

Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype IgM
Clone Names M-T6004
Additional Information
Other Species Rainbow Trout
Purification Purified IgM prepared by gel filtration from tissue culture supernatant
Immunogen Purified CD60 antigen from PBL; 9-O-acetyl-GD3 from buttermilk
Shelf Life 18 months from date of despatch.
Target/Specificity Mouse anti-Human CD60 antibody, clone M-T6004 recognizes the human CD60 antigen, a carbohydrate structure GD3 (Neu5Aca8Neu5Aca3Galβ4GlcCer) modified by a terminal 9-0-acetylated disialosyl group (9-O-acetyl GD3). Mouse anti-human CD60 antibody clone M-T6004 does not recognize 7-O-acetyl GD3 or non-acetylated GD3. CD60 has been divided into 3 sub-types depending on the acetylation present. Non acetylated GD3 is termed CD60a and 7-O-acetyl GD3 termed CD60c. 9-O-acetyl GD3 as recognized by clone M-T6004 has been designated CD60b.CD60b is present on CD8+ve helper T cells (Rieber and Rank 1994), CD4+ve memory T cells and on activated B cells (Vateret al.1997). Expression has also been reported on neuroectodermal cells (Carret al.1995) and in breast carcinomas (Gochtet al.1998). CD60b is not expressed by naive T cells (Wadaet al.1998). GD3 has been described as a pro-apoptotic messenger targeting mitochondria in many lymphoid and myeloid cell types (García-Ruizet al.2000). Acetylation abrogates the pro-apoptotic activity of GD3 (Malisanet al.2002) and CD60b protects tumor cells from apoptosis (Kniepet al.2006).
Preservative & Stabilisers 0.09% Sodium Azide
Storage Store at +4℃ or at -20 ℃.
PrecautionsAnti-Human CD60 Antibody, clone M-T6004 is for research use only and not for use in diagnostic or therapeutic procedures.
Citations (0)

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1. Rieber, E. P. and Rank, G. (1994) CDw60: a marker for human CD8+ T helper cells.
J. Exp. Med. 179: 1385-1390. 2. Saalmuller, A. et al. (2007) Summary of the animal homologue section of HLDA8.
Vet Immunol Immunopathol. 119: 2-13. 3. Malisan, F. et al. (2002) Acetylation suppresses the proapoptotic activity of GD3 ganglioside.
J Exp Med. 196: 1535-41. 4. Kniep, B. et al. (2006) 9-O-acetyl GD3 protects tumor cells from apoptosis.
Int J Cancer. 119: 67-73. 5. Erdmann, M. et al. (2006) Differential surface expression and possible function of 9-O- and 7-O-acetylated GD3 (CD60 b and c) during activation and apoptosis of human tonsillar B and T lymphocytes.
Glycoconj J. 23: 627-38. 6. Fischer, U. and Koellner, B. (2007) Cross-reactivity of human leukocyte differentiation antigen monoclonal antibodies on carp and rainbow trout cells.
Vet Immunol Immunopathol. 119: 142-55. 7. Mukherjee, K. et al. (2008) O-acetylation of GD3 prevents its apoptotic effect and promotes survival of lymphoblasts in childhood acute lymphoblastic leukaemia
J Cell Biochem. 105: 724-34.

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Cat# ABD11567
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