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Mouse Anti-Human Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-F, FC, IP |
|---|---|
| Primary Accession | P11230 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgG1 |
| Clone Names | B3 |
| Calculated MW | 56698 Da |
| Purification | Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant |
|---|---|
| Immunogen | Human Acetylcholine Receptor (AChR). |
| Shelf Life | 18 months from date of despatch. |
| Gene ID | 1140 |
| Other Names | Acetylcholine receptor subunit beta, CHRNB1, ACHRB, CHRNB |
| Target/Specificity | Mouse anti-Human Acetylcholine Receptor beta antibody, clone B3 exhibits homogenous, high avidity binding to the beta subunit of nicotinc AChR, an integral membrane and cholinergic receptor, consisting of four further subunits: alpha, delta, gamma (immature muscle) and epsilon (mature muscle). The binding of the neurotransmitter acetylcholine to AChR, results in conformational change affecting all subunits, and initiates the opening of an ion-conducting channel across the plasma membrane of certain neurons, and neuromuscular junctions.Mouse anti-Human Acetylcholine Receptor beta antibody, clone B3 has been shown to bind to recombinant AChR beta in Western blotting |
| Preservative & Stabilisers | 0.09% Sodium Azide |
| Storage | Store at +4℃ or at -20 ℃. |
| Precautions | Anti-Human Acetylcholine Receptor beta Antibody, clone B3 is for research use only and not for use in diagnostic or therapeutic procedures. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
References
1. Whiting, P.J. et al. (1986) Monoclonal Antibodies that distinguish between normal and denervated human acetylcholine receptor. J. Neuroimmunol. 11: 223-235. 2. Roberts, A. et al. (1992) Search for cross reactive idiotypes on monoclonal and myasthenia gravis acetylcholine receptor antibodies.Autoimmunity 21: 53-60. 3. Heidenreich F. et al. (1988) Differences in fine specificity of anti-acetylcholine receptor antibodies between subgroups of spontaneous myasthenia gravis of recent onset and of penicillamine induced myasthenia.Autoimmunity 2: 31-37. 4. Whiting, P. et al. (1986) Myasthenia gravis: Monoclonal anti-human acetylcholine receptor antibodies used to analyse antibody specificities and responses to treatment.Neurology 36: 612-617. 5. Schluep, M. et al. (1987) Acetylcholine receptors in human thymic myoid cells in situ: An immunohistological study.Annals of Neurology 22: 212-222.
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