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>   home   >   Products   >   Primary Antibodies   >   Stem Cells   >   Anti-Mouse CD31 Antibody, clone 2H8    

Anti-Mouse CD31 Antibody, clone 2H8

Hamster Anti-Mouse Monoclonal Antibody

Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IF, FC, Func
Primary Accession Q08481
Reactivity Mouse
Host Hamster
Clonality Monoclonal
Isotype IgG
Clone Names 2H8
Calculated MW 81263 Da
Additional Information
Purification Purified IgG prepared by Caprylic Acid Precipitation
Immunogen D10.G4.1 cells (Kayeet al.1984).
Shelf Life 18 months from date of despatch.
Gene ID 18613
Other Names Platelet endothelial cell adhesion molecule, PECAM-1, CD31, Pecam1, Pecam, Pecam-1
Target/Specificity Hamster anti-Mouse CD31 monoclonal antibody, clone 2H8 recognizes murine CD31, also known as Platelet endothelial cell adhesion molecule or PECAM-1. CD31 is a ~130kDa single pass type-1 membrane glycoprotein bearing six C2 Ig-like domains, expressed on all continuous endothelium including arteries, veins and non-sinusoidal capillaries. CD31 is also expressed on all haemopoietic lineages with the exception of the erythroid line (Bogenet al.1992) . Hamster anti-mouse CD31, clone 2H8 effectively inhibits transmigration of activated polymorphonuclear cells and monocytes across the endothelium. In a mouse model for acute peritonitis clone 2H8 blocks acute inflammation (Bogenet al.1994). CD31 has also been shown to be critically involved in the sensing of changes in shear stress associated with atherosclerotic lesions and in the associated atherogenesis (Stevenset al.2008).
Preservative & Stabilisers Preservative Free
Storage Store at -20℃ only.
PrecautionsAnti-Mouse CD31 Antibody, clone 2H8 is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
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1. Bogen, S.A. et al. (1992) Association of murine CD31 with transmigrating lymphocytes following antigenic stimulation.
Am J Pathol. 141 (4): 843-54. 2. Xie, Y. & Muller, W.A. (1993) Molecular cloning and adhesive properties of murine platelet/endothelial cell adhesion molecule 1.
Proc. Natl. Acad. Sci. 90: 5569-5573. 3. Bogen, S. et al. (1994) Monoclonal antibody to murine PECAM-1 (CD31) blocks acute inflammation in vivo.
J. Exp. Med. 179: 1059-1064. 4. Bixel, M.G. et al. (2010) CD99 and CD99L2 act at the same site as, but independently of, PECAM-1 during leukocyte diapedesis.
Blood. 116: 1172-84. 5. Ishikawa, J. et al. (2002) Use of anti-platelet-endothelial cell adhesion molecule-1 antibody in the control of disease progression in established collagen-induced arthritis in DBA/1J mice.
Jpn J Pharmacol. 88: 332-40. 6. Thurston, G. et al (2005) Angiopoietin 1 causes vessel enlargement, without angiogenic sprouting, during a critical developmental period
Development. 132: 3317-26. 7. Lonsdorf, A.S. et al. (2012) Engagement of aIIbß3 (GPIIb/IIIa) with a?ß3 Integrin Mediates Interaction of Melanoma Cells with Platelets: A CONNECTION TO HEMATOGENOUS METASTASIS.
J Biol Chem. 287: 2168-78. 8. Rijcken, E. et al. (2007) PECAM-1 (CD 31) mediates transendothelial leukocyte migration in experimental colitis.
Am J Physiol Gastrointest Liver Physiol. 293: G446-52. 9. Vielhauer, V. et al. (2005) Renal cell-expressed TNF receptor 2, not receptor 1, is essential for the development of glomerulonephritis.
J Clin Invest. 115: 1199-209. 10. Brackett, C.M. et al. (2013) IL-17 promotes neutrophil entry into tumor-draining lymph nodes following induction of sterile inflammation.
J Immunol. 191 (8): 4348-57. 11. Bixel, M.G. et al. (2010) CD99 and CD99L2 act at the same site as, but independently of, PECAM-1 during leukocyte diapedesis.
Blood. 116: 1172-84. 12. Wu, Y. et al. (2010) Therapeutic antibody targeting of individual Notch receptors.
Nature. 464: 1052-7. 13. Wilhelm, A. et al. (2015) CD248/endosialin critically regulates hepatic stellate cell proliferation during chronic liver injury via a PDGF-regulated mechanism.
Gut. pii: gutjnl-2014-308325.

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Cat# ABD11575
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