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Anti-Human TNF alpha Antibody, clone 4C6-H6

Mouse Anti-Human Monoclonal Antibody

Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P01375
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype IgM
Clone Names 4C6-H6
Calculated MW 25644 Da
Additional Information
Purification Tissue Culture Supernatant containing 0.2M Tris/HCl pH7.4 and 5-10% foetal calf serum
Immunogen 115-130 AA sequence linked to thyroglobulin
Shelf Life 18 months from date of despatch.
Gene ID 7124
Other Names Tumor necrosis factor, Cachectin, TNF-alpha, Tumor necrosis factor ligand superfamily member 2, TNF-a, Tumor necrosis factor, membrane form, N-terminal fragment, NTF, Intracellular domain 1, ICD1, Intracellular domain 2, ICD2, C-domain 1, C-domain 2, Tumor necrosis factor, soluble form, TNF, TNFA, TNFSF2
Target/Specificity Mouse anti-Human TNF alpha antibody clone 4C6-H6 recognizes human Tumor necrosis factor, also known as TNF alpha, Cachectin or Tumor necrosis factor ligand superfamily member 2. TNFα is a 233 amino acid ~22kDa type II transmembrane protein with a single potential glycosylation site (Uniprot P01375:Takakura-Yamamotoet al.1996). Mouse anti-Human TNF alpha antibody clone 4C6-H6 has been used successfully for the demonstration of TNFα expression in formalin fixed, paraffin embedded bone marrow biopsies from patients with Myelodysplastic syndrome (Molnáret al.2000) ant has been used for evaluating the increase in TNFα expression seen in peripheral blood mononuclear cells from patients suffering from the autoinnmuse condition, Graves disease (Quadbecket al.2006).
Preservative & Stabilisers 0.09% Sodium Azide
Storage Store at +4℃ or at -20 ℃.
PrecautionsAnti-Human TNF alpha Antibody, clone 4C6-H6 is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
Citations (0)

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1. Bebôk, Zs., Márkus, B., Németh, P. (1994) Prognostic relevance of transforming growth factor alpha (TGF-alpha) and tumor necrosis factor alpha (TNF-alpha) detected in breast cancer tissues by immunohistochemistry.
Breast Cancer Res. Treat. 29: 229-235. 2. Molnár, L. et al. (2000) Detection of TNFalpha expression in the bone marRow and determination of TNFalpha production of peripheral blood mononuclear cells in myelodysplastic syndrome.
Pathol. Oncol. Res. 6: 18-23. 3. Togo, T. et al. (2001) Glial involvement in the degeneration process of Lewy body-bearing neurons and the degradation process of Lewy bodies in brains of dementia with Lewy bodies.
J Neurol Sci. 184: 71-5. 4. Brown, H. et al. (1999) Cytokine expression in the brain in human cerebral malaria.
J Infect Dis. 180: 1742-6. 5. Quadbeck, B. et al. (2006) Dysregulation of TNF/TNFR superfamily members: a systemic link between intra- and extrathyroidal manifestations in Graves' disease.
Scand J Immunol. 64: 523-30.

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Cat# ABD11577
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