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Anti-Sheep Interleukin-1 beta Antibody, clone 1D4

Mouse Anti-Sheep Monoclonal Antibody

  • E - Anti-Sheep Interleukin-1 beta Antibody, clone 1D4  ABD11608
    Published customer image:Mouse anti Sheep interleukin 1β antibody, clone 1D4 used as a capture reagent for the measurement of interleukin 1β in an ELISA using lamb sera.Image caption:Systemic and diaphragm cytokine responses. Plasma IL-1ß (A) and IL-6 (B) protein content. Values are mean ± SEM. Diaphragm IL-1ß (C) and IL-6 (D) mRNA expression. Values are median (with 10th and 90th centiles). * p
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P21621
Reactivity Sheep
Host Mouse
Clonality Monoclonal
Isotype IgG1
Clone Names 1D4
Calculated MW 30717 Da
Additional Information
Other Species Ga,B,Hs
Immunogen Recombinant ovine IL-1 Beta
Shelf Life 18 months from date of despatch.
Gene ID 443539
Other Names Interleukin-1 beta, IL-1 beta, IL1B
Target/Specificity Mouse anti-Sheep Interleukin-1 beta antibody, clone 1D4 recognizes ovine interleukin-1 beta, and shows no cross-reactivity with ovine IL-6, IL-8, TNF alpha or MCP-1.Mouse anti-Sheep Interleukin-1 beta antibody, clone 1D4 demonstrates partial neutralizing activity of ovine IL-1 beta.
Preservative & Stabilisers 0.09% Sodium Azide
Storage Store at +4℃ or at -20 ℃.
PrecautionsAnti-Sheep Interleukin-1 beta Antibody, clone 1D4 is for research use only and not for use in diagnostic or therapeutic procedures.
Citations (0)

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1. Rothel, J.S. et al. (1997) Analysis of ovine IL-1 beta production in vivoandin vitro by enzyme immunoassay and immunohistochemistry.
Vet. Immunol. Immunopathol. 57: 267-278. 2. Martoriati, A. & Gérard, N. (2003) Interleukin-1 (IL-1) system gene expression in granulosa cells: kinetics during terminal preovulatory follicle maturation in the mare.
Reprod Biol Endocrinol. 1: 42-51. 3. Wenz, J.R. et al. (2010) Factors associated with concentrations of select cytokine and acute phase proteins in dairy cows with naturally occurring clinical mastitis.
J Dairy Sci. 93: 2458-70. 4. Rinaldi, M. et al (2010) A sentinel function for teat tissues in dairy cows: dominant innate immune response elements define early response to E. colimastitis.
Funct Integr Genomics. 10: 21-38. 5. Bougarn, S. et al. (2010) Muramyl dipeptide synergizes with Staphylococcus aureus lipoteichoic acid to recruit neutrophils in the mammary gland and to stimulate mammary epithelial cells.
Clin Vaccine Immunol. 17 (11): 1797-809. 6. Bannerman, D.D. et al. (2004) Escherichia coli and Staphylococcus aureus elicit differential innate immune responses following intramammary infection.
Clin Diagn Lab Immunol. 11: 463-72. 7. Simojoki, H. et al. (2011) Innate immune response in experimentally induced bovine intramammary infection with Staphylococcus simulansandS. epidermidis.
Vet Res. 42: 49. 8. Redondo, E. et al. (2014) Induction of interleukin-8 and interleukin-12 in neonatal ovine lung following experimental inoculation of bovine respiratory syncytial virus.
J Comp Pathol. 150 (4): 434-48. 9. Karisnan K et al. (2015) Interleukin-1 Receptor Antagonist Protects against Lipopolysaccharide Induced Diaphragm Weakness in Preterm Lambs.
PLoS One. 10 (4): e0124390. 10. Dernfalk, J. et al. (2007) The xMAP technique can be used for detection of the inflammatory cytokines IL-1beta, IL-6 and TNF-alpha in bovine samples.
Vet Immunol Immunopathol. 118 (1-2): 40-9. 11. Leite, F. et al. (2005) Incubation of bovine PMNs with conditioned medium from BHV-1 infected peripheral blood mononuclear cells increases their susceptibility to Mannheimia haemolyticaleukotoxin.
Vet Immunol Immunopathol. 103 (3-4): 187-93. 12. Jacobsen, S. et al. (2007) The cytokine response of circulating peripheral blood mononuclear cells is changed after intravenous injection of lipopolysaccharide in cattle.
Vet J. 174 (1): 170-5. 13. Cox, R.A. et al. (2007) Production of pro-inflammatory polypeptides by airway mucous glands and its potential significance.
Pulm Pharmacol Ther. 20 (2): 172-7. 14. Bannerman, D.D. et al. (2004) Characterization of the bovine innate immune response to intramammary infection with Klebsiella pneumoniae.
J Dairy Sci. 87 (8): 2420-32. 15. Rainard P et al.(2008)Staphylococcus aureus lipoteichoic acid triggers inflammation in the lactating bovine mammary gland.
Vet Res. 39 (5): 52. 16. Matthews, K. et al. (2007) The effect of gene gun-delivered pGM-CSF on the immunopathology of the vaccinated skin.
Scand J Immunol. 65 (3): 298-307. 17. Xu, A. et al. (2015) The Ovine Fetal and Placental Inflammatory Response to Umbilical Cord Occlusions With Worsening Acidosis.
Reprod Sci. pii: 1933719115580994.

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