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>   home   >   Products   >   Primary Antibodies   >   Anti-Mouse NC1.1 Antibody, clone IC4    

Anti-Mouse NC1.1 Antibody, clone IC4

Mouse Anti-Mouse Monoclonal Antibody

Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, FC, IP, Func
Reactivity Mouse
Host Mouse
Clonality Monoclonal
Isotype IgG1
Clone Names IC4
Additional Information
Purification Purified IgG prepared by affinity chromatography on Protein G
Immunogen Spleen cells from CBA mice
Shelf Life 18 months from date of despatch.
Target/Specificity Mouse anti-Mouse NC1.1 antibody, clone IC4 recognizes an alloantigen designated NC1.1 expressed by murine natural cytotoxic cells. (NC1.1 is a 45kDa cell surface antigen).Natural cytotoxic cells represent a small subset of cells with cytotoxic activity against certain tumor cells in functional assays. Mouse anti-Mouse NC1.1 antibody, clone IC4 has been shown to block substantially NC cells activity in vivoandin vitro.Mouse anti-Mouse NC1.1 antibody, clone IC4 recognizes the NC1.1 alloantigen in CBA, C57BL/6, BALB/c and NZB mice, but not in CE or DBA/2 mice.
Preservative & Stabilisers Preservative Free
Storage Storage at -20℃ only.
PrecautionsAnti-Mouse NC1.1 Antibody, clone IC4 is for research use only and not for use in diagnostic or therapeutic procedures.
Citations (0)

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1. Smart, Y.C. et al. (1990) Production of a monoclonal allo-antibody to murine natural cytotoxic cells.
Immunol. Cell Biol. 68: 277-284. 2. Smart, Y.C. et al. (1990) Natural Cytotoxic cells and tumour surveillance in vivo.
Eur. J. Cancer 26: 863-864. 3. Smart, Y.C. et al. (1992) Correlation of growth of tumours in NC-cell depleted mice with NC- and NK-cell mediated lysis in vitro.
Int. J. Cancer 50: 817-821. 4. Brien, J.H. et al. (1994) Phenotype and morphology of murine NC1.1+ natural cytotoxic cells.
Immunol. Cell. Biol. 72: 161-168. 5. Holmgreen, S.P. et al. (1997) Phosphorylation of the NC-1.1 receptor and regulation of natural cytotoxicity by Protein kinase C and cyclic GMP-dependent protein kinase.
J. Immunol. 158: 2035-2041.

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Cat# ABD11628
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