|Application ||WB, FC, IP, Func|
|Purification||Purified IgG prepared by affinity chromatography on Protein G|
|Immunogen||Spleen cells from CBA mice|
|Shelf Life||18 months from date of despatch.|
|Target/Specificity||Mouse anti-Mouse NC1.1 antibody, clone IC4 recognizes an alloantigen designated NC1.1 expressed by murine natural cytotoxic cells. (NC1.1 is a 45kDa cell surface antigen).Natural cytotoxic cells represent a small subset of cells with cytotoxic activity against certain tumor cells in functional assays. Mouse anti-Mouse NC1.1 antibody, clone IC4 has been shown to block substantially NC cells activity in vivoandin vitro.Mouse anti-Mouse NC1.1 antibody, clone IC4 recognizes the NC1.1 alloantigen in CBA, C57BL/6, BALB/c and NZB mice, but not in CE or DBA/2 mice.|
|Preservative & Stabilisers||Preservative Free|
|Storage||Storage at -20℃ only.|
|Precautions||Anti-Mouse NC1.1 Antibody, clone IC4 is for research use only and not for use in diagnostic or therapeutic procedures.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
1. Smart, Y.C. et al. (1990) Production of a monoclonal allo-antibody to murine natural cytotoxic cells.Immunol. Cell Biol. 68: 277-284. 2. Smart, Y.C. et al. (1990) Natural Cytotoxic cells and tumour surveillance in vivo.Eur. J. Cancer 26: 863-864. 3. Smart, Y.C. et al. (1992) Correlation of growth of tumours in NC-cell depleted mice with NC- and NK-cell mediated lysis in vitro.Int. J. Cancer 50: 817-821. 4. Brien, J.H. et al. (1994) Phenotype and morphology of murine NC1.1+ natural cytotoxic cells.Immunol. Cell. Biol. 72: 161-168. 5. Holmgreen, S.P. et al. (1997) Phosphorylation of the NC-1.1 receptor and regulation of natural cytotoxicity by Protein kinase C and cyclic GMP-dependent protein kinase.J. Immunol. 158: 2035-2041.
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