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Anti-MBP (aa82-91) Antibody, clone 10 (Ascites)

Mouse Anti-Bovine Monoclonal Antibody

Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P02687
Reactivity Bovine
Host Mouse
Clonality Monoclonal
Isotype IgG2a
Clone Names 10
Calculated MW 18323 Da
Additional Information
Immunogen Bovine Myelin Basic protein (MBP) (45-91) / Ovalbumin Conjugate
Shelf Life 18 months from date of despatch.
Other Names Myelin basic protein, MBP, 20 kDa microtubule-stabilizing protein, Myelin A1 protein, MBP
Target/Specificity Mouse anti-Human MBP antibody, clone 10 recognizes the synthetic peptide 82-91 and human and bovine 45-91 but not with whole native MBP molecule (Martensen numbering). This epitope is located in the C terminal region of 82-91 and the corresponding epitope is not present (or exposed) in whole MBP.The clone was selected using synthetic human MBP peptide 82-91 for screening (Groome, N.P. et al1985). Since this work was done a sequence error has been described in the human MBP sequence in this region (Gibson,et al.1984).Although the clone was selected to have a high affinity for 82-91 it appears that this antibody reacts more strongly with the unnatural sequence, rather than the correct human 82-91. In consequence the antibody is not a suitable reagent for sensitive immunoassays of correct human 82-91 as was thought at the time the original paper on this antibody was published.The 91-92 phe-phe bond is believed to be cleaved by demyelinating lesions by Cathepsin D to generate peptides ending in the phe 91 which should react with this monoclonal.
Preservative & Stabilisers 0.09% Sodium Azide
Storage Store at +4℃ or at -20 ℃.
PrecautionsAnti-MBP (aa82-91) Antibody, clone 10 (Ascites) is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
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1. Groome, N.P., Harland, J. and Dawkes, A. (1985) Preparation and characterisation of monoclonal antibodies to myelin basic protein and its peptides.
Neurochemistry International. 7: 309-317. 2. Martensen, R.W. (1984) in Experimental Allergic Encephalomyelitis.
A useful model for multiple sclerosis (Alvord E.C., Kies, M.W. and Suckling, A.J. eds). pp 511-521 Alan Liss N.Y. 3. Gibson, B.W., Gilliom, R.D., Whitaker, J.N. and Bieman, K. (1984) Amino acid sequence of human myelin basic protein peptide 45-89 as determined by mass spectrometry.
J. Biol. Chem. 259: 5028-5031. 4. Sakuma, H. et al. (2006) Quantitation of myelin oligodendrocyte glycoprotein and myelin basic protein in the thymus and central nervous system and its relationship to the clinicopathologic features of autoimmune encephalomyelitis.
J Neurosci Res. 84: 606-13.

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Cat# ABD11646
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