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Rat Anti-Human Monoclonal Antibody
- SPECIFICATION
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- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | P04049 |
| Reactivity | Human |
| Host | Rat |
| Clonality | Monoclonal |
| Isotype | IgG1 |
| Clone Names | pS338 (DPR/2/2A/3A) |
| Calculated MW | 73052 Da |
| Purification | Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant |
|---|---|
| Immunogen | Synthetic peptide GQRDS*SYY*WEIEAS coupled to glutaraldehyde. |
| Shelf Life | 18 months from date of despatch. |
| Gene ID | 5894 |
| Other Names | RAF proto-oncogene serine/threonine-protein kinase, 2.7.11.1, Proto-oncogene c-RAF, cRaf, Raf-1, RAF1, RAF |
| Target/Specificity | Rat anti-Human RAF-1 (pSer338) antibody, clone pS338 recognizes activated human RAF proto-oncogene serine/threonine-protein kinase, also known as Raf-1 or c-RAF, binding to the phosphorylated serine residue at position 338.Rat anti-Human RAF-1 (pSer338) antibody, clone pS338 binds to Raf-1 that has been activated by Ras or Src, but not to unactivated Raf-1. Rat anti-Human RAF-1 (pSer338) antibody, clone pS338 does not bind to Raf peptides phosphorylated at other sites, including Y341 and S339.Rat anti-Human RAF-1 (pSer338) antibody, clone pS338 has been described for the detection of Ser338 phosphorylated RAF-1 by western blotting (Masonet al.1999). |
| Preservative & Stabilisers | 0.09% Sodium Azide |
| Storage | Store at +4℃ or at -20 ℃. |
| Precautions | Anti-Human RAF-1 (pSer338) Antibody, clone pS338 (DPR/2/2A/3A) is for research use only and not for use in diagnostic or therapeutic procedures. |
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Provided below are standard protocols that you may find useful for product applications.
References
1. Mason, C.S. et al. (1999) Serine and tyrosine phosphorylations co-operate in Raf-1, but not B-Raf activation EMBO. J. 18: 2137-2148 2. Chiloeches, A. et al. (2001) S338 phosphorylation of Raf-1 is independent of phosphatidylinositol 3-kinase and Pak3.Mol Cell Biol. 21: 2423-34.
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