|Application ||IHC-F, FC|
|Shelf Life||18 months from date of despatch.|
|Target/Specificity||Mouse anti-Dog MHC Class II Monomorphic antibody, clone CA2.1C12 recognizes a monomorphic epitope on canine MHC Class II which was classified at the First Canine Leucocyte Antigen Workshop (CLAW) [Cobboldet al.1992]. In dogs, MHC Class II is expressed by all peripheral blood mononuclear cells.The major histocompatibility complex (MHC) is a cluster of genes that are important in the immune response to infections. In dogs, this is referred to as the dog leukocyte antigen (DLA) region.|
|Preservative & Stabilisers||0.09% Sodium Azide|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Dog MHC Class II Monomorphic Antibody, clone CA2.1C12 is for research use only and not for use in diagnostic or therapeutic procedures.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
1. Cobbold, S. & Metcalfe, S. (1994) Monoclonal antibodies that define canine homologues of human CD antigens: Summary of the First International Canine Leukocyte Antigen Workshop (CLAW).Tissue Antigens 43: 137-154. 2. Wang, Y.S. et al. (2007) Characterization of canine monocyte-derived dendritic cells with phenotypic andfunctional differentiation. PubMed PMID:Can J Vet Res. 71: 165-74. 3. Veenhof, E.Z. et al. (2011) Characterisation of T cell phenotypes, cytokines and transcription factors in the skin of dogs with cutaneous adverse food reactions.Vet J. 187 (3): 320-4. 4. Caniatti, M. et al. (1996) Canine lymphoma: immunocytochemical analysis of fine-needle aspiration biopsy.Vet Pathol. 33: 204-12. 5. Huang, Y.C. et al. (2008) CD5-low expression lymphocytes in canine peripheral blood show characteristics of natural killer cells.J Leukoc Biol. 84: 1501-10. 6. Isotani, M. et al. (2006) Efficient generation of canine bone marrow-derived dendritic cells.J Vet Med Sci. 68: 809-14. 7. Liu, C.C. et al. (2008) Transient downregulation of monocyte-derived dendritic-cell differentiation, function, and survival during tumoral progression and regression in an in vivo canine model of transmissible venereal tumor.Cancer Immunol Immunother. 57: 479-91. 8. McDonough, S.P. and Moore, P.F. (2000) Clinical, hematologic, and immunophenotypic characterization of canine large granular lymphocytosis.Vet Pathol. 37: 637-46. 9. Pumarola, M. et al. (2004) Canine inflammatory myopathy: analysis of cellular infiltrates.Muscle Nerve. 29: 782-9. 10. Ricklin, Gutzwiller. M.E. et al. (2010) Comparative analysis of canine monocyte- and bone-marrow-derived dendritic cells.Vet Res. 41: 40. 11. Yuasa, K. et al. (2007) Injection of a recombinant AAV serotype 2 into canine skeletal muscles evokes strong immune responses against transgene products.Gene Ther. 14: 1249-60.
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