|Application ||WB, IHC-F, IP|
|Calculated MW||347603 Da|
|Immunogen||Recombinant protein corresponding to amino acids 1844 - 2131 of huntingtin.|
|Shelf Life||18 months from date of despatch.|
|Other Names||Huntingtin, Huntington disease protein, HD protein, HTT, HD, IT15|
|Target/Specificity||Mouse anti-Huntingtin antibody, clone HDB4E10 reacts with an epitope corresponding to the HDB region (amino acids 1844 - 2131) of the huntingtin protein.Mouse anti-Huntingtin antibody, clone HDB4E10 detects a ~350 kDa band on western blots but also detects smaller degradation products of huntingtin. The combined use of Mouse anti-Huntingtin antibody, clones HDB4E10 (ABD11683), HDC8A4 (MCA2051) and HDA3E10 (MCA2049) demonstrate that huntingtin is enriched in neuronal cells in the brain (Jones 1999).|
|Preservative & Stabilisers||0.09% Sodium Azide|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Huntingtin Antibody, clone HDB4E10 is for research use only and not for use in diagnostic or therapeutic procedures.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
1. Wilkinson, F. L. et al. (1999) Localization of rabbit huntingtin using a new panel of monoclonal antibodies.Molecular Brain Research. 69: 10-20. 2. Yao Y et al. (2015) A striatal-enriched intronic GPCR modulates huntingtin levels and toxicity.Elife. 4: 4. 3. Shirasaki, D.I. et al. (2012) Network organization of the huntingtin proteomic interactome in mammalian brain.Neuron. 75 (1): 41-57. 4. Jones, A.L. (1999) The localization and interactions of huntingtin.Philos Trans R Soc Lond B Biol Sci. 354 (1386): 1021-7. 5. Tao, T. & Tartakoff, A.M. (2001) Nuclear relocation of normal huntingtin.Traffic. 2 (6): 385-94. 6. Massai, L. et al. (2013) Development of an ELISA assay for the quantification of soluble huntingtin in human blood cells.BMC Biochem. 14: 34.
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