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>   home   >   Products   >   Primary Antibodies   >   Immunology   >   Anti-Human Placental Alkaline Phosphatase Antibody, clone H17E2    

Anti-Human Placental Alkaline Phosphatase Antibody, clone H17E2

Mouse Anti-Human Monoclonal Antibody

  • FC - Anti-Human Placental Alkaline Phosphatase Antibody, clone H17E2  ABD11694
    Published customer image:Mouse anti Human placental alkaline phosphatase antibody, clone H17E2 used for the detection of PLAP reporter expression on peripheral blood granulocytes by flow cytometrry.Image caption:Figure 3. Activation of the Cre-reporter gene is less efficient in Z/AP and Z/EG mice than in R26R-EYFP mice. All reporter strains were crossed to the general deleter strain, pCX-NLS-Cre, and activation of each reporter gene was assessed by flow cytometry of peripheral blood leukocytes at 12 weeks of age (A). All reporter strains were also crossed to the myeloid-specific LysM-Cre strain, and activation of each reporter gene was assessed by flow cytometry of peripheral blood granulocytes at 12 weeks of age (B). Representative histograms demonstrating reporter expression in peripheral blood granulocytes are shown in (C–E) for LysM-Cre/R26R-EYFP, LysM-Cre/ZAP and LysM-Cre/Z/EG mice respectively (solid lines). Reporter expression in BL/6 mice is shown in dotted lines.From: Long MA, Rossi FMV Silencing Inhibits Cre-Mediated Recombination of the Z/AP and Z/EG Reporters in Adult Cells. PLoS ONE 4: e5435.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P05187
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype IgG1
Clone Names H17E2
Calculated MW 57954 Da
Additional Information
Purification Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant.
Immunogen Placental membrane.
Shelf Life 18 months from date of despatch.
Gene ID 250
Other Names Alkaline phosphatase, placental type,, Alkaline phosphatase Regan isozyme, Placental alkaline phosphatase 1, PLAP-1, ALPP, PLAP
Target/Specificity Mouse anti-Human placental alkaline phosphatase antibody, clone H17E2 recognizes human placental alkaline phosphatase, also known as Alkaline phosphatase Regan isozyme, Alkaline phosphatase, placental type or Placental alkaline phosphatase 1. Placental alkaline phosphatase is a 535 amino acid ~67 kDa GPI-anchored transmembrane glycoprotein bearing a 22 amino acid signal peptide and a 29 amino acid pro-peptide region, cleaved to produce the mature form. Placental alkaline phosphatase is expressed in trophoblast cells of normal human placenta (Traverset al.1984), in seminomas (Langeet al.1982)and in ovarian carcinoma (Tholanderet al.1990).Mouse anti-Human placental alkaline phosphatase antibody, clone H17E2 has been widely used in immunolocalization studies of germ cell tumours and may also be used for the measurement of soluble placental alkaline phosphatase by ELISA.
Preservative & Stabilisers 0.09% Sodium Azide
Storage Store at +4℃ or at -20 ℃.
PrecautionsAnti-Human Placental Alkaline Phosphatase Antibody, clone H17E2 is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
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1. Travers, P. & Bodmer, W. (1984) Preparation and characterization of monoclonal antibodies against placental alkaline phosphatase and other human trophoblast-associated determinants.
Int J Cancer. 33 (5): 633-41. 2. Tucker, D.F. et al. (1985) Serum marker potential of placental alkaline phosphatase-like activity in testicular germ cell tumours evaluated by H17E2 monoclonal antibody assay.
Br J Cancer. 51 (5): 631-9. 3. Epenetos, A.A. et al. (1984) An immunohistological study of testicular germ cell tumours using two different monoclonal antibodies against placental alkaline phosphatase.
Br J Cancer. 49 (1): 11-5. 4. Kalofonos, H.P. et al. (1990) Immunolocalisation of testicular tumours using radiolabelled monoclonal antibody to placental alkaline phosphatase.
J Nucl Med Allied Sci. 34 (4): 294-8. 5. Long, M.A. & Rossi, F.M. (2009) Silencing inhibits Cre-mediated recombination of the Z/AP and Z/EG reporters in adult cells.
PLoS One. 4:e5435. 6. Carter, C.C. et al. (2010) HIV-1 infects multipotent progenitor cells causing cell death and establishing latent cellular reservoirs.
Nat Med. 16: 446-51. 7. Wonderlich, E.R. et al. (2011) ADP Ribosylation Factor 1 Activity Is Required To Recruit AP-1 to the Major Histocompatibility Complex Class I (MHC-I) Cytoplasmic Tail and Disrupt MHC-I Trafficking in HIV-1-Infected Primary T Cells.
J Virol. 85: 12216-26. 8. Semenov, O.V. et al. (2010) Multipotent mesenchymal stem cells from human placenta: critical parameters for isolation and maintenance of stemness after isolation.
Am J Obstet Gynecol. 202:193.e1-193.e13. 9. Göhner, C. et al. (2015) A New Enzyme-linked Sorbent Assay (ELSA) to Quantify Syncytiotrophoblast Extracellular Vesicles in Biological Fluids.
Am J Reprod Immunol. 73 (6): 582-8. 10. Fisken, J. et al. (1989) Serum placental-like alkaline phosphatase (PLAP): a novel combined enzyme linked immunoassay for monitoring ovarian cancer.
J Clin Pathol. 42 (1): 40-5. 11. Orozco AF et al. (2009) Placental release of distinct DNA-associated micro-particles into maternal circulation: reflective of gestation time and preeclampsia.
Placenta. 30 (10): 891-7. 12. Dankers, P.Y.W. et al. (2015) Convenient formulation and application of a supramolecular ureido-pyrimidinone modified poly(ethylene glycol) carrier for intrarenal growth factor delivery
European Polymer Journal. Jul 2 [Epub ahead of print]

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