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>   home   >   Products   >   Primary Antibodies   >   Immunology   >   Anti-Human Granzyme A Antibody, clone GA6    

Anti-Human Granzyme A Antibody, clone GA6

Mouse Anti-Human Monoclonal Antibody

Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P12544
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype IgG1
Clone Names GA6
Calculated MW 28999 Da
Additional Information
Purification Purified IgG prepared by affinity chromatography on Protein A from tissue culture supernatant
Immunogen Recombinant human Granzyme A.
Shelf Life 18 months from date of despatch.
Gene ID 3001
Other Names Granzyme A,, CTL tryptase, Cytotoxic T-lymphocyte proteinase 1, Fragmentin-1, Granzyme-1, Hanukkah factor, H factor, HF, GZMA, CTLA3, HFSP
Target/Specificity Mouse anti-Human granzyme A antibody, clone GA6 recognizes Granzyme A, a ~60 kDa disulphide-linked homodimeric protein of two 262 amino acid chains, expressed in cytoplasmic granules of cytotoxic lymphocytes and NK cells.Granzyme A is involved in the induction of apoptosis via its activity as a serine protease, but this would seem to be subsidiary to the role of Granzyme B. Granzyme A deficient mice are indistinguishable from normal animals in their response to infection.Granzyme A has been proposed as a potential biomarker for patients with active tuberculosis with significantly lower levels present in the plasma of patients with the active form of the disease compared to patients with latent infection (Gugginoet al.2015)
Preservative & Stabilisers 0.09% Sodium Azide
Storage Store at +4℃ or at -20 ℃.
PrecautionsAnti-Human Granzyme A Antibody, clone GA6 is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
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1. Kummer, J. A. et al. (1993) Production and characterisation of monoclonal antibodies raised against recombinant human granzymes A and B and showing cross reactions with the natural proteins.
J. Immunol. Methods. 163: 77-83. 2. Mahrus, S. & Craik, C.S. (2005) Selective chemical functional probes of granzymes A and B reveal granzyme B is a major effector of natural killer cell-mediated lysis of target cells.
Chem Biol. 12: 567-77. 3. Meade, J.L. et al. (2009) Proteolytic activation of the cytotoxic phenotype during human NK cell development.
J Immunol. 183: 803-13. 4. Hochegger, K. et al. (2007) Expression of granzyme A in human polymorphonuclear neutrophils.
Immunology. 121: 166-73. 5. Grodzovski, I. et al. (2011) IL-2-granzyme A chimeric protein overcomes multidrug resistance (MDR) through a caspase 3-independent apoptotic pathway.
Int J Cancer. 128: 1966-80. 6. Suck, G. et al. (2005) KHYG-1, a model for the study of enhanced natural killer cell cytotoxicity.
Exp Hematol. 33: 1160-71. 7. Vrazo, A.C. et al. (2015) Live cell evaluation of granzyme delivery and death receptor signaling in tumor cells targeted by human natural killer cells.
Blood. 126 (8): e1-e10.

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Cat# ABD11705
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