Foundational characteristics of cancer include proliferation, angiogenesis, migration, evasion of apoptosis, and cellular immortality. Find key markers for these cellular processes and antibodies to detect them.
The SUMOplot™ Analysis Program predicts and scores sumoylation sites in your protein. SUMOylation is a post-translational modification involved in various cellular processes, such as nuclear-cytosolic transport, transcriptional regulation, apoptosis, protein stability, response to stress, and progression through the cell cycle.
The Autophagy Receptor Motif Plotter predicts and scores autophagy receptor binding sites in your protein. Identifying proteins connected to this pathway is critical to understanding the role of autophagy in physiological as well as pathological processes such as development, differentiation, neurodegenerative diseases, stress, infection, and cancer.Anti-Sheep MHC Class II DQ DR Polymorphic Antibody, clone 49.1 (FITC)
Mouse Anti-Sheep Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| FC |
|---|---|
| Reactivity | Sheep |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgG2a |
| Clone Names | 49.1 |
| Other Species | Ga,H,B |
|---|---|
| Purification | Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant |
| Shelf Life | 18 months from date of despatch. |
| Target/Specificity | Mouse anti-Sheep MHC class II Dq DR antibody, clone 49.1 recognizes a polymorphic epitope on ovine MHC class II DQ and DR molecules, constitutively expressed on antigen presenting cells including dendritic cells, B lymphocytes, monocytes, macrophages, activated T lymphocytes and may be induced on a range of other cell types by interferon gamma.The major histocompatibility complex (MHC) is a cluster of genes some of which are important in the immune response to infection. In sheep, this complex is referred to as the ovine leukocyte antigen (OLA) region. There are 2 major types of MHC class IIa molecules encoded by the OLA which are DR and DQ each composed of an alpha and beta chain.Mouse anti-Sheep MHC class II Dq DR antibody, clone 49.1 recognizes ovine MHC II transfectants DQ - T28.1, DQ - T26.2 and DR - T31.3 but not DR - T8.1 (Ballingallet al.1995). |
| Preservative & Stabilisers | 0.09% Sodium Azide (NaN3); 1% Bovine Serum Albumin |
| Storage | Store at +4℃ or -20℃. |
| Precautions | Anti-Sheep MHC Class II DQ DR Polymorphic Antibody, clone 49.1 (FITC) is for research use only and not for use in diagnostic or therapeutic procedures. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abgent.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
References
1. Puri, N.K. et al. (1987) Monoclonal antibodies to sheep MHC class I and class II molecules: biochemical characterization of three class I gene products and four distinct subpopulations of class II molecules.Vet Immunol Immunopathol. 15 (1-2): 59-86. 2. Puri, N.K. & Brandon, M.R. (1987) Sheep MHC class II molecules. II. Identification and characterization of four distinct subsets of sheep MHC class II molecules.Immunology. 62 (4): 575-80. 3. Puri, N.K. et al. (1987) Monoclonal antibodies to sheep MHC class II molecules recognize all HLA-D or subsets of HLA-D region products.Hum Immunol. 20 (3): 195-207. 4. Ballingall, K.T. et al. (1995) Analysis of the fine specificities of sheep major histocompatibility complex class II-specific monoclonal antibodies using mouse L-cell transfectants.Anim Genet. 26 (2): 79-84. 5. Kallapur, S.G. et al. (2011) Pulmonary and systemic inflammatory responses to intra-amniotic IL-1α in fetal sheep.Am J Physiol Lung Cell Mol Physiol. 301 (3): L285-95. 6. Gorrell, M.D. et al. (1988) Lymphocyte phenotypes in the intestinal mucosa of sheep infected with
Trichostrongylus colubriformis.Clin Exp Immunol. 72 (2): 274-9. 7. Stenfeldt, C. et al. (2015) Clinical and virological dynamics of a serotype O 2010 South East Asia lineage foot-and-mouth disease virus in sheep using natural and simulated natural inoculation and exposure systems.Vet Microbiol. pii: S0378-1135(15)00149-2. 8. Tripp, R. et al. (2015) Pathogenesis of Primary Foot-and-Mouth Disease Virus Infection in the Nasopharynx of Vaccinated and Non-Vaccinated CattlePLOS ONE. 10 (11): e0143666.
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at tech@abgent.com.
Ordering Information
Shipping Information
