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>   home   >   Products   >   Primary Antibodies   >   Cardiovascular   >   Anti-Human Podoplanin Antibody, clone 4D5aE5E6    

Anti-Human Podoplanin Antibody, clone 4D5aE5E6

Mouse Anti-Human Monoclonal Antibody

Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q86YL7
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype IgG1
Clone Names 4D5aE5E6
Calculated MW 16698 Da
Additional Information
Purification Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
Immunogen ORF Human podoplanin ectodomain expressed in E.coli
Shelf Life 18 months from date of despatch.
Gene ID 10630
Other Names Podoplanin, Aggrus, Glycoprotein 36, Gp36, PA2.26 antigen, T1-alpha, T1A, PDPN {ECO:0000312|EMBL:AAH14668.2}
Target/Specificity ABD11767 recognizes Human Podoplanin (gp36), a 36kDa type I cell membrane-associated glycoprotein, with a broad spectrum of distribution, being strongly expressed on the lymphatic endothelium found in lung, placenta and skeletal muscle and to a lesser extent in brain, kidney and liver.Podoplanin is absent on blood endothelium and therefore ABD11767 is readily able to distinguish between lymphatic vessels and blood vasculature. Although the specific function of this protein is undetermined, Podoplanin is reported to be a reliable indicator of tumour lymphangiogenesis.
Preservative & Stabilisers 0.09% Sodium Azide
Storage Store at +4℃ or at -20 ℃.
PrecautionsAnti-Human Podoplanin Antibody, clone 4D5aE5E6 is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
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1. Furtado, G.C. et al. (2007) Lymphotoxin beta receptor signaling is required forinflammatory lymphangiogenesis in the thyroid.
Proc Natl Acad Sci U S A. 104: 5026-31. 2. Pardo, J. et al. (2007) Pseudomesotheliomatous carcinoma of the lung with a distinct morphology, immunohistochemistry, and comparative genomic hybridization profile.
Ann Diagn Pathol. 11: 241-51. 3. Link, A. et al. (2011) Association of T-zone reticular networks and conduits with ectopic lymphoid tissues in mice and humans.
Am J Pathol. 178: 1662-75. 4. Gu, Y. et al. (2008) Lymphangiogenesis induced by VEGF-C and VEGF-D promotes metastasis and a poor outcome in breast carcinoma: a retrospective study of 61 cases.
Clin Exp Metastasis. 25: 717-25. 5. Ra, S.H. et al. (2007) Recurrent hepatic lymphangiomatosis after orthotopic liver transplantation.
Liver Transpl. 13: 1593-7.1. Matsui, K. et al. (2003) Lymphatic microvessels in the rat remnant kidney model of renal fibrosis: Aminopeptidase P and Podoplanin are discriminatory markers for endothelial cells of blood and lymphatic vessels.
J. Am. Soc. Nephrol. 14: 1981-1989.2. Dadras, S. S. et al. (2003) Tumor Lymphangiogenesis: A novel prognostic indicator for cutaneous melanoma metastasis and survival.
Am. J. Pathol. 162(6): 1951-1960.3. Kato, Y. et al. (2003) Molecular Identification of Aggrus/T1alpha as a Platelet Aggregation-inducing Factor Expressed in Colorectal Tumors.
J. Biol Chem 278(51): 51599-51605.4. Schacht, V. et al. (2003) T1alpha/podoplanin deficiency disrupts normal lymphatic vasculature formation and causes lymphedema.
EMBO J. 22(14): 3546-3556.5. Zimmer, G. et al. (1999) Cloning and characterization of gp36, a human mucin-type glycoprotein preferentially expressed in vascular endothelium.
Biochem J. 341: 277-284.

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Cat# ABD11767
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