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Anti-FYN Antibody, clone FYN-01

Mouse Anti-Human Monoclonal Antibody

Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P06241
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype IgG2b
Clone Names FYN-01
Calculated MW 60762 Da
Additional Information
Other Species M
Purification Purified IgG prepared by affinity chromatography on Protein A from tissue culture supernatant
Immunogen Bacterially expressed recombinant fragment of human fyn aa 7-176.
Shelf Life 18 months from date of despatch.
Gene ID 2534
Other Names Tyrosine-protein kinase Fyn,, Proto-oncogene Syn, Proto-oncogene c-Fyn, Src-like kinase, SLK, p59-Fyn, FYN
Target/Specificity ABD11773 recognizes p59fyn (fyn), a 59kDa member of the src family of non receptor protein tyrosine kinases, expressed by T cells and Natural Killer (NK) cells and highly expressed in brain.Fyn plays a vital role in thymocyte development and T cell activation and is essential for TCR-mediated signal transduction through association with the T Cell Receptor (TCR) eta chain/CD3 Complex. This association, results in protein kinase activation and the subsequent protein tyrosine phosphorylation of multiple immunoreceptor tyrosine-based activation motifs (ITAMs), which triggers the phosphorylation of further substrates downstream in the T cell signaling cascade.Recent studies into Alzheimer’s Disease have implicated fyn in neurodegeneration, through the tyrosine phosphorylation of the microtubule-associated protein tau, a prominent component of neurofibrillary tangles.
Preservative & Stabilisers 0.09% Sodium Azide
Storage Store at +4℃ or at -20 ℃.
PrecautionsAnti-FYN Antibody, clone FYN-01 is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
Citations (0)

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1. Meraner, P. et al. (2007) Dendritic cells sensitize TCRs through self-MHC-mediated Src family kinase activation.
J Immunol. 178:2262-71.1. Ho, G.J. et al. (2005) Altered p59Fyn kinase expression accompanies disease progression in Alzheimer’s disease: implications for its functional role.
Neurobiol. Aging. 26: 625-35.2. Lee, G. et al. (2004) Phosphorylation of Tau by Fyn: Implications for Alzheimer’s disease.
J. Neuroscience 24:2304-12.3. Olszowy, M.W. et al. (1995) Comparison of p56lck and p59fyn protein expression in thymocyte subsets, peripheral T cells, NK cells and lymphoid cell lines.
J. Immunol. (1995). 155(9):4236-4240.4. Zamoyska, R. et al. (2003) The influence of the src-family kinases Lck and Fyn, on T cell differentiation, survival and activation.
Immunol. Rev. 191:107-118.

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Cat# ABD11773
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