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Anti-Syk Antibody, clone SYK-01

Mouse Anti-Human Monoclonal Antibody

Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P43405
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype IgG1
Clone Names SYK-01
Calculated MW 72066 Da
Additional Information
Other Species M,Rat
Purification Purified IgG prepared by affinity chromatography on Protein A from tissue culture supernatant
Immunogen Recombinant fragment corresponding to amino acids 5 - 360 of human syk.
Shelf Life 18 months from date of despatch.
Gene ID 6850
Other Names Tyrosine-protein kinase SYK,, Spleen tyrosine kinase, p72-Syk, SYK
Target/Specificity ABD11776 recognizes protein tyrosine kinase p72syk (syk), a 72kDa non-receptor tyrosine kinase, critical for immunoreceptor signaling in haematopoietic cells, but also expressed by nonhaematopoietic cells, including fibroblasts, endothelial cells and hepatocytes.Syk plays an important role in mast cell response, initiated by the aggregation of the IgE high affinity receptor Fc epsilon R1. Phosphorylation of ITAMs within Fc receptor R1 by another tyrosine kinase lyn, results in the recruitment of syk, which is then responsible for the further phosphorylation of numerous target proteins within many different signal transduction pathways.Further studies have shown that syk also plays a major role in B cell receptor-mediated apoptosis, proliferation and haematopoiesis. Syk is also reported to associate with protein kinase C alpha during platelet activation.
Preservative & Stabilisers 0.09% Sodium Azide
Storage Store at +4℃ or at -20 ℃.
PrecautionsAnti-Syk Antibody, clone SYK-01 is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
Citations (0)

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1. Amoui, M. et al. (1997) Direct interaction of Syk and Lyn protein tyrosine kinases in rat basophilic leukemia cells activated via type I Fc epsilon receptors.
Eur. J. Immunol. 27(1): 321-328. 2. Tolar, P. et al. (1997) Protein tyrosine kinase Syk is involved in Thy-1 signaling in rat basophilic leukemia cells.
Eur. J. Immunol. 27(12): 3389-3397. 3. Manetz, T.S. et al. (2001) Vav1 regulates phospholipase C gamma activation and calcium responses in mast cells.
Mol. Cell. Biol. 21(11): 3763-3774. 4. Swann, al. (1999) Requirement for a negative charge at Threonine 60 of the FcR gamma for complete activation of Syk.
J. Biol. Chem. 274(33): 23068-23077. 5. Arudchandran, al. (2000) The src homology 2 domain of Vav is required for its compartmentation to the plasma membrane and activation of c-Jun NH2-terminal kinase 1.
J. Exp. Med. 191(1): 47-59.

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Cat# ABD11776
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