|Application ||WB, IHC-F|
|Calculated MW||98981 Da|
|Purification||Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant|
|Immunogen||Synthetic phosphopeptide corresponding to an amino acid sequence within human progesterone receptor which includes phosphorylated Ser 294.|
|Shelf Life||18 months from date of despatch.|
|Other Names||Progesterone receptor, PR, Nuclear receptor subfamily 3 group C member 3, PGR, NR3C3|
|Target/Specificity||This product is specific for both the PR-A and PR-B isoforms of human progesterone receptor, when phosphorylated at serine 294. Progesterone receptor (PR) is a member of the steroid hormone receptor superfamily, and is expressed in a range of tissues, including ovary, endometrium, uterus and placenta, and may play a key role in the regulation and differentiation of mammary glands, The detection of estrogen (ER) and progesterone (PR) receptors using immunohistochemical staining , has gradually replaced ligand binding assays (LBA), to become the most common method for the determination of the ER/PR status of breast tumors. Approximately 75% to 80% of breast tumors have estrogen and/or progesterone receptors, and the presence of these receptors helps determine both the patient’s prognosis and the effectiveness of hormonal therapy.|
|Preservative & Stabilisers||0.09% Sodium Azide|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Progesterone Receptor (pSer294) Antibody, clone 608 is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
1. Zhang, Y. et al. (1997) Phosphorylation of human progesterone receptor by cyclin-dependent kinase 2 on three sites that are authentic basal phosphorylation sites in vivo.Mol. Endocrinol. 11: 823 - 832.
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