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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   Anti-Progesterone Receptor (pSer294) Antibody, clone 608    

Anti-Progesterone Receptor (pSer294) Antibody, clone 608

Mouse Anti-Human Monoclonal Antibody

  • WB - Anti-Progesterone Receptor (pSer294) Antibody, clone 608  ABD11782
    Western blot of whole cell T47D lysate prepared from cells that had been incubated in the presence of synthetic progetin agonst R5020 (500 nm) showing phosphospecific immunolabeling of the ~90 kDa PR-A isoform and the ~120 kDa PR-B isoform of the progesterone receptor phosphorylated at Ser294
  • IHC - Anti-Progesterone Receptor (pSer294) Antibody, clone 608  ABD11782
    Immunoperoxidase staining of human breast carcinoma with Mouse anti Human progesterone receptor antibody . High power
  • IHC - Anti-Progesterone Receptor (pSer294) Antibody, clone 608  ABD11782
    Immunoperoxidase staining of human breast carcinoma with Mouse anti Human progesterone receptor antibody . Low power
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P06401
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype IgG1
Clone Names 608
Calculated MW 98981 Da
Additional Information
Purification Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
Immunogen Synthetic phosphopeptide corresponding to an amino acid sequence within human progesterone receptor which includes phosphorylated Ser 294.
Shelf Life 18 months from date of despatch.
Gene ID 5241
Other Names Progesterone receptor, PR, Nuclear receptor subfamily 3 group C member 3, PGR, NR3C3
Target/Specificity This product is specific for both the PR-A and PR-B isoforms of human progesterone receptor, when phosphorylated at serine 294. Progesterone receptor (PR) is a member of the steroid hormone receptor superfamily, and is expressed in a range of tissues, including ovary, endometrium, uterus and placenta, and may play a key role in the regulation and differentiation of mammary glands, The detection of estrogen (ER) and progesterone (PR) receptors using immunohistochemical staining , has gradually replaced ligand binding assays (LBA), to become the most common method for the determination of the ER/PR status of breast tumors. Approximately 75% to 80% of breast tumors have estrogen and/or progesterone receptors, and the presence of these receptors helps determine both the patient’s prognosis and the effectiveness of hormonal therapy.
Preservative & Stabilisers 0.09% Sodium Azide
Storage Store at +4℃ or at -20 ℃.
PrecautionsAnti-Progesterone Receptor (pSer294) Antibody, clone 608 is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
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1. Zhang, Y. et al. (1997) Phosphorylation of human progesterone receptor by cyclin-dependent kinase 2 on three sites that are authentic basal phosphorylation sites in vivo.
Mol. Endocrinol. 11: 823 - 832.

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Cat# ABD11782
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