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Anti-Mouse Notch 1 Antibody, clone mN1A

Mouse Anti-Mouse Monoclonal Antibody

  • FC - Anti-Mouse Notch 1 Antibody, clone mN1A  ABD11783
    Staining of mouse thymocytes with Mouse anti Mouse NOTCH 1:Alexa Fluor® 488
  • FC - Anti-Mouse Notch 1 Antibody, clone mN1A  ABD11783
    Staining of mouse thymocytes with Mouse anti Mouse NOTCH-1:Alexa Fluor® 647
  • FC - Anti-Mouse Notch 1 Antibody, clone mN1A  ABD11783
    Staining of mouse thymocytes with Mouse anti Mouse NOTCH-1:FITC
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q01705
Reactivity Mouse
Host Mouse
Clonality Monoclonal
Isotype IgG1
Clone Names mN1A
Calculated MW 270835 Da
Additional Information
Other Species H
Purification Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
Immunogen Synthetic peptide corresponding to cdc10-NCR region within mouse Notch1.
Shelf Life 18 months from date of despatch.
Gene ID 18128
Other Names Neurogenic locus notch homolog protein 1, Notch 1, Motch A, mT14, p300, Notch 1 extracellular truncation, NEXT, Notch 1 intracellular domain, NICD, Notch1, Motch
Target/Specificity Mouse anti-Mouse Notch 1 antibody, clone mN1A specifically recognizes Notch 1, one of the four major transmembrane receptors (Notch 1-4) of the Notch signalling pathway, which is activated through binding to DSL domain-containing membrane-bound specific ligands. The Notch signalling pathway is an evolutionarily conserved pathway in multi-cellular organisms, which is vital for cell-cell communication, important during fundamental developmental and physiological processes, including regulation of cell fate decisions during neuronal, cardiac and endocrine development, stem cell haematopoiesis, thymic T-cell development, and both tumour progression and suppression. Ligation of Notch receptors by their specific ligands, Jagged1 (CD339), Jagged2, Delta like-1 (DLL1), DLL3 and DLL4, on physically adjacent signal receiving cells, induces proteolysis of the receptors by ADAM-family metalloproteases and gamma-secretase complex, within the transmembrane domain, releasing the Notch intracellular domain (NICD) to translocate to the nucleus. Subsequent signal transduction then occurs through either the CSL-NICD-Mastermind complex cascade (canonical pathway), or NF-kappaB-NICD and CSL-NICD-Deltex complex signalling cascades (non-canonical pathway). The canonical pathway inhibits the differentiation of stem cells or progenitor cells, whilst the non-canonical pathway promotes differentiation.Notch 1 is expressed in a range of cells including haematopoietic cells in mouse foetal liver, adult thymus and bone marrow. Notch 1 signalling plays a role in follicular differentiation, tissue homeostasis, and in both CD4+ and CD8+ cell maturation in the thymus. Studies have also implicated Notch 1 in the regulation of lymphopoeisis, myelopoiesis, and neurogenesis.
Preservative & Stabilisers 0.09% Sodium Azide
Storage Store at +4℃ or at -20 ℃.
PrecautionsAnti-Mouse Notch 1 Antibody, clone mN1A is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
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1. Ray, W.J. et al. (1999) Evidence for a physical interaction between presenilin and Notch.
Proc. Natl. Acad. Sci. USA. 96:3263-3268. 2. Huppert, S.S. et al. (2000) Embryonic lethality in mice homozygous for a processing-deficient allele of Notch1.
Nature 405: 966-970. 3. Espinosa, L. et al. (2002) p65-NFkappa B synergizes with Notch to activate transcription by triggering cytoplasmic translocation of the nuclear receptor corepressor N-CoR.
J. Cell. Sci. 115: 1295-1303. 5. Ren, M. and Cowell, J.K. (2011) Constitutive Notch pathway activation in murine ZMYM2-FGFR1-induced T-cell lymphomas associated with atypical myeloproliferative disease.
Blood. 117: 6837-47.4. Kang-Decker, N. et al. (2004) Loss of CBP causes T cell lymphomagenesis in synergy with p27Kip1 insufficiency.
Cancer Cell. 5: 177-189.

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Cat# ABD11783
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