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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   Anti-Human PAG Antibody, clone MEM-255    

Anti-Human PAG Antibody, clone MEM-255

Mouse Anti-Human Monoclonal Antibody

Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9NWQ8
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype IgG2a
Clone Names MEM-255
Calculated MW 46981 Da
Additional Information
Purification Purified IgG prepared by affinity chromatography on Protein A
Immunogen Recombinant intracellular fragment (amino acids 97-432) of human Cbp/PAG
Shelf Life 18 months from date of despatch.
Gene ID 55824
Other Names Phosphoprotein associated with glycosphingolipid-enriched microdomains 1, Csk-binding protein, Transmembrane adapter protein PAG, Transmembrane phosphoprotein Cbp, PAG1, CBP, PAG
Target/Specificity Mouse anti-Human PAG antibody, clone MEM-255 recognizes humanr Phosphoprotein Associated with Glycosphingolipid-enriched microdomains (PAG), also known as csk-binding protein (Cbp) or Transmembrane phosphoprotein Cbp. PAG is a single pass type II transmembrane protein. Mouse anti-Human PAG antibody, clone MEM-255 recognizes an epitope (aa 235-280) located in the cytoplasmic domain which localizes to membrane lipid rafts and is involved in regulation of T-Cell activation.The engagement of immunoreceptors with natural ligands or antibodies is the initiating factor in a long line of events down a cytosolic signaling cascade. The transmission of signals along the various pathways within this cascade requires the phosphorylation of various substrates, by members of the src and syk families of protein tyrosine kinases (PTKs).Evidence has shown that by binding to the SH2 domain of the PTK csk, a major negative regulator of src-family kinases, PAG acts not only acts as a ‘co-factor’ for relocating csk to substrate rich microdomains, but also increases the affinity of csk for src-family kinases, through the formation of PAG-csk complexes.
Preservative & Stabilisers 0.09% Sodium Azide
Storage Store at +4℃ or at -20 ℃.
PrecautionsAnti-Human PAG Antibody, clone MEM-255 is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
Citations (0)

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1. Brdickova, N et al. (2001) Interaction between two adapter proteins, PAG and EBP50: a possible link between membrane rafts and actin cytoskeleton.
FEBS Lett. 507: 133-136.1. Brdicka, T. et al. (2000) Phosphoprotein associated with glycosphingolipid-enriched microdomains (PAG), a novel ubiquitously expressed transmembrane adaptor protein, binds the protein tyrosine kinase Csk and is involved in regulation of T cell activation.
J. Exp. Med. 191(9): 1591-1604.2. Ohtake, H. et al. (2002) Cutting Edge: Transmembrane phosphoprotein Csk-binding protein/phosphoprotein associated with glycosphingolipid-enriched microdomains as a negative feedback regulator of mast cell signaling through the FcepsilonRI.
J. Immunol. 168: 2087-2090.

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Cat# ABD11786
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