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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   Anti-Human iC3b (Neoantigen) Antibody, clone 013III-1.16    

Anti-Human iC3b (Neoantigen) Antibody, clone 013III-1.16

Mouse Anti-Human Monoclonal Antibody

Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P01024
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype IgG2b
Clone Names 013III-1.16
Calculated MW 187148 Da
Additional Information
Purification Purified IgG prepared by affinity chromatography on Protein A
Immunogen Purified human iC3b
Shelf Life 18 months from date of despatch.
Gene ID 718
Other Names Complement C3, C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1, Complement C3 beta chain, C3-beta-c, C3bc, Complement C3 alpha chain, C3a anaphylatoxin, Acylation stimulating protein, ASP, C3adesArg, Complement C3b alpha' chain, Complement C3c alpha' chain fragment 1, Complement C3dg fragment, Complement C3g fragment, Complement C3d fragment, Complement C3f fragment, Complement C3c alpha' chain fragment 2, C3, CPAMD1
Target/Specificity ABD11830 recognises 42kDa human inactive complement component 3b (iC3b) neoantigen present in blood serum. Cleavage of C3b into iC3b by the protease factor I, in the presence of cofactors, changes the structure and resulting binding properties, preventing binding by complement factor B and properdin. This prevents further progression of the complement pathway, providing another mechanism by which the complement pathway may be regulated. iC3b is thought to play a role in inducing tolerance, binding complement receptor type 3 on antigen presenting cells and stimulating them to produce transforming growth factor beta2 and interleukin-10. It is thought to stimulate B-cells via the CD21 receptor providing a link between the innate and adaptive immune responses. Additionally iC3b acts as an opsonin which is recognised by complement receptor 3 expressed on leukocytes or complement receptor of the immunoglobulin superfamily (CRIg) on Kupffer cells, stimulating phagocytosis of the tagged cells. iC3b levels are often elevated in diseases such as Systemic Lupus Erythematosis and Rheumatoid arthritis.
Preservative & Stabilisers 0.09% Sodium Azide
Storage Store at +4℃ or at -20 ℃.
PrecautionsAnti-Human iC3b (Neoantigen) Antibody, clone 013III-1.16 is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
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1. Janssena, B. et al. (2007) Structural insights into the central complement component C3.
Molecular Immunology. 44: 3-10. 2. Bergmann-Leitner, E. et al. (2006) Complement 3d: From molecular adjuvant to target of immune escape mechanisms.
Clinical Immunology121: 177-185.3. Sohn, J. H. et al. (2003) Tolerance is dependent on complement C3 fragment iC3b binding to antigen-presenting cells.
Nature Medicine 9: 206-212.

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Cat# ABD11830
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