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Anti-ATIC Antibody, clone F38 P7 H9

  • IHC - Anti-ATIC Antibody, clone F38 P7 H9  ABD11840
    Staining of paraffin embedded human colon carcinoma with Mouse anti Human ATIC
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P31939
Host Mouse
Clonality Monoclonal
Isotype IgG1
Clone Names F38 P7 H9
Calculated MW 64616 Da
Additional Information
Other Species Rat,M,D,X,H
Purification Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
Immunogen Ovalbumin-conuugated synthetic peptide AHTNLRLFHH
Shelf Life 18 months from date of despatch.
Gene ID 471
Other Names Bifunctional purine biosynthesis protein PURH, Phosphoribosylaminoimidazolecarboxamide formyltransferase,, 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase, AICAR transformylase, IMP cyclohydrolase,, ATIC, IMP synthase, Inosinicase, ATIC, PURH
Target/Specificity Mouse anti-ATIC antibody, clone F38 P7 H9 specifically recognizes ATIC,a ribonucleotide transformylase (AICAR transformylase) and member of the purH family, which helps catalyze the final steps of the purine biosynthesis pathway. ATIC has been identified as an activator of AMP-activated protein kinase (AMPK), a known regulator of energy homeostasis, inhibitor of cell proliferation and inducer of apoptosis in cancerous cells of various origins, making ATIC a potential therapeutic agent for cancer. The anti-inflammatory and neuroprotective functions of ATIC, also have implications for its use in the treatment of Alzheimer's disease.
Preservative & Stabilisers 0.09% Sodium Azide
Storage Store at +4℃ or at -20 ℃.
PrecautionsAnti-ATIC Antibody, clone F38 P7 H9 is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
Citations (0)

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1. Rattan, R. et al. (2005) 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside inhibits cancer cell proliferation in vitroandin vivo via AMP-activated protein kinase.
J. Biol. Chem. 280: 39582-39593.

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Cat# ABD11840
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