|Calculated MW||57305 Da|
|Purification||Antisera to human alkaline phosphatase were raised by repeated immunisations of sheep with highly purified antigen. Purified IgG prepared by affinity chromatography on protein G.|
|Immunogen||Alkaline phosphatase from human bone|
|Shelf Life||18 months from the date of despatch.|
|Other Names||Alkaline phosphatase, tissue-nonspecific isozyme, AP-TNAP, TNSALP, 188.8.131.52, Alkaline phosphatase liver/bone/kidney isozyme, ALPL|
|Target/Specificity||Sheep anti-Human alkaline phosphatase (Bap) antibody recognizes human bone alkaline phosphatase (BAP), a membrane-bound hydrolase enzyme expressed by osteoblast cells.Alkaline phosphatase (AP) is a ubiquitously expressed enzyme which removes phosphate groups from target molecules, including DNA, RNA and alkaloids, under alkaline conditions, and is present at higher concentrations in the placenta (placental AP), intestines (intestinal AP) and liver/bone/kidney (tissue non-specific AP). Although the exact biochemical function of BAP is uncertain, measurement of the serum levels of BAP can be used as a biochemical indicator of bone turnover. Conditions which present with a decrease in the level of BAP (hypophosphatasemia) include the inherited bone-deforming disorder hypophosphatasia and osteoporosis, whilst an increase in BAP (hyperphosphatasemia) is associated with Paget’s disease, bone fractures and osteosarcomas.|
|Preservative & Stabilisers||0.09% Sodium Azide|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Human Alkaline Phosphatase (Bap) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
1. Farley, J.R. and Baylink, D.J. (1995) Skeletal alkaline phosphatase activity in serum. Clin. Chem. 41: 1551-1553.
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