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>   home   >   Products   >   Primary Antibodies   >   Cardiovascular   >   Anti-Human Fibrinogen Antibody (FITC)   

Anti-Human Fibrinogen Antibody

Sheep Anti-Human Polyclonal Antibody

Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P02679
Other Accession P02671, P02675
Reactivity Human
Host Sheep
Clonality Polyclonal
Isotype Polyclonal IgG
Calculated MW 51512 Da
Additional Information
Other Species M,Rat
Purification Purified IgG prepared by ion exchange chromatography
Immunogen Human fibrinogen purified from plasma.
Shelf Life 18 months from the date of despatch.
Gene ID 2266
Other Names Fibrinogen gamma chain, FGG
Target/Specificity Sheep anti-Human fibrinogen antibody recognizes human fibrinogen, a complex ~340kDa hetero-hexameric (di-trimeric) glycoprotein consisting of 3 pairs of α, β and γ chains linked by a series of 29 disulphide bonds (Henschenet al.1983). The six chains are arranged in such a way that all the N-Terminal ends adjoin to form a central E domain with two trimeric coiled coil structures connecting to outer D domains. Fibrinogen plays an important role in the coagulation process with the D and E domains interacting via the C-Terminal ends of the α chains during fibrin clot cross-linking. Sheep anti-human fibrinogen antibody shows minimal cross-reactivity with related serum proteins. Fibrinogen has been identified as a ferritin binding protein in the horse (Orinoet al.1993). Sheep anti-human fibrinogen antibody has been successfully as a capture reagent for ferritin - anti-ferritin IgG complexes in horse plasma to evaluate the antibody response to ferritin by ELISA (Takahashiet al.2013).
Preservative & Stabilisers 0.09% Sodium Azide (NaN3)
Storage Store at +4℃ or at -20 ℃.
PrecautionsAnti-Human Fibrinogen Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
Citations (0)

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1. Brill, A. et al. (2011) von Willebrand factor-mediated platelet adhesion is critical for deep vein thrombosis in mouse models.
Blood. 117: 1400-7. 2. Barrera, V. et al. (2011) Host fibrinogen stably bound to hemozoin rapidly activates monocytes via TLR-4 and CD11b/CD18-integrin: a new paradigm of hemozoin action.
Blood. 117: 5674-82. 3. Grainger, D.J. et al. (2004) Apolipoprotein E modulates clearance of apoptotic bodies in vitro and in vivo, resulting in a systemic proinflammatory state in apolipoprotein E-deficient mice.
J Immunol. 173: 6366-75. 4. Grainger, D.J. et al. (2001) Suppressing Thrombin Generation is Compatible With the Development of Atherosclerosis in Mice
Thromb Res. 102: 71-80. 5. Chien, H.W. (2013) Surface conjugation of zwitterionic polymers to inhibit cell adhesion and protein adsorption.
Colloids Surf B Biointerfaces. 107: 152-9. 6. Plskova, J. et al. (2004) Quantitative evaluation of the corneal endothelium in the mouse after grafting.
Br J Ophthalmol. 88: 1209-16. 7. Takahashi, K. et al. (2013) The presence of heat-labile factors interfering with binding analysis of fibrinogen with ferritin in horse plasma.
Acta Vet Scand. 55: 70. 8. Ozaltin, F. et al. (2013) DGKE variants cause a glomerular microangiopathy that mimics membranoproliferative GN.
J Am Soc Nephrol. 24: 377-84. 9. Dmitrieva, N.I. and Burg, M.B. (2014) Secretion of von Willebrand factor by endothelial cells links sodium to hypercoagulability and thrombosis.
Proc Natl Acad Sci U S A. 111: 6485-90. 10. Johnsen, D. et al. (2015) Disrupting protein tyrosine phosphatase σ does not prevent sympathetic axonal dieback following myocardial infarction
Experimental Neurology. Nov 23 [Epub ahead of print]1. Kamath, S. and Lip, G.Y. (2003) Fibrinogen: biochemistry, epidemiology and determinants.
Q.J.M. 96: 711-729.2. Mosesson, M.W. (2005) Fibrinogen and fibrin structure and functions.
J. Thromb. Haemost. 3: 1894-1904.

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Cat# ABD11893
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