|Calculated MW||45205 Da|
|Purification||Purified IgG prepared by affinity chromatography on Protein G|
|Immunogen||Native, purified human haptoglobin from serum.|
|Shelf Life||18 months from the date of despatch.|
|Other Names||Haptoglobin, Zonulin, Haptoglobin alpha chain, Haptoglobin beta chain, HP|
|Target/Specificity||Sheep anti-Human Haptoglobin antibody detects haptoglobin, also known as Hp, an acute phase plasma glycoprotein synthesized by the liver in response to infection or inflammation. Haptoglobin binds haemoglobin released by erythrocytes with high affinity, and functions to block the oxidative activity of haemoglobin and prevent renal damage. The haptoglobin-haemoglobin complex is rapidly removed from the circulation by monocytes and macrophages, via the receptor CD163.The haptoglobin genotype has been demonstrated to be an independent risk factor for cardiovascular disease in multiple epidemiological studies.|
|Preservative & Stabilisers||0.09% Sodium Azide (NaN3)|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Human Haptoglobin Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
1. Carter, K. and Worwood, M. (2007) Haptoglobin: a review of the major allele frequencies worldwide and their association with diseases.Int. J. Lab. Hematol. 29: 92-110. 2. Guetta, J. et al. (2007) Haptoglobin genotype modulates the balance of Th1/Th2 cytokines produced by macrophages exposed to free hemoglobin.Atherosclerosis. 191: 48-53. 3. Araki, H. et al. (2015) Haptoglobin promoter polymorphism rs5472 as a prognostic biomarker for peptide vaccine efficacy in castration-resistant prostate cancer patients.Cancer Immunol Immunother. Oct 1. [Epub ahead of print] 4. Soejima, M. et al. (2014) Genetic factors associated with serum haptoglobin level in a Japanese population.Clin Chim Acta. 433: 54-7.
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