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Rabbit Anti-Mouse Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E, Func |
|---|---|
| Primary Accession | P07750 |
| Reactivity | Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Polyclonal IgG |
| Calculated MW | 15834 Da |
| Purification | Antisera to mouse IL-4 were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG was prepared by affinity chromatography. |
|---|---|
| Immunogen | Recombinant mouse IL-4 |
| Shelf Life | 12 months from date of reconstitution. |
| Gene ID | 16189 |
| Other Names | Interleukin-4, IL-4, B-cell IgG differentiation factor, B-cell growth factor 1, B-cell stimulatory factor 1, BSF-1, IGG1 induction factor, Lymphocyte stimulatory factor 1, Il4, Il-4 |
| Target/Specificity | Rabbit anti-Mouse Interleukin-4 antibody recognizes mouse interleukin-4 (IL-4), also known as B-cell stimulatory factor 1, a 120 amino acid pleiotropic cytokine cleaved from a 140 amino acid precursor which interacts with multiple cell lineages, including T cells, fibroblasts and macrophages (Crawfordet al.1987).Interleukin-4 is one of the most important factors involved in B cell IgG1 and IgE class switching (Winteret al.1987). IL-4 acts as a regulator of low affinity Fc receptor for IgE (CD23) expression on both lymphocytes and monocytes (Miyajimaet al.1991,Hudaket al.1987). IL-4 acts through binding to it's cognate receptor CD124, a receptor which also binds the related cytokine IL-13.Interleukin -4 plays an important role in the alternative activation of murine macrophages as indicated by the ability to potently up-regulate the expression and activity of CD206, the macrophage mannose receptor (Steinet al.1992). |
| Preservative & Stabilisers | Preservative Free |
| Storage | Prior to reconstitution store at +4℃. Following reconstitution store at -20℃. |
| Precautions | Anti-Mouse Interleukin-4 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
References
1. de Barros, V.E.D. et al. (2011) An Experimental Model of Meningoencephalomyelitis by Rocio Flavivirus in Balb/C Mice: Inflammatory Response, Cytokine Production, and Histopathology Am J Trop Med Hyg. 85: 363-73. 2. Kim, S.R. et al. (2013) Endoplasmic reticulum stress influences bronchial asthma pathogenesis by modulating nuclear factor ?B activation.J Allergy Clin Immunol. pii: S0091-6749(13)01382-1.
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