|Application ||WB, E, Func|
|Calculated MW||26416 Da|
|Purification||Antisera to human Flt3-Ligand were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG prepared by affinity chromatography.|
|Immunogen||Recombinant human Flt3-Ligand.|
|Shelf Life||12 months from date of reconstitution.|
|Other Names||Fms-related tyrosine kinase 3 ligand, Flt3 ligand, Flt3L, SL cytokine, FLT3LG|
|Target/Specificity||Rabbit anti-Human Flt3 Ligand antibody recognizes the ubiquitously expressed human growth factor Flt3-Ligand (Flt3L), a 235aa type I transmembrane glycoprotein which regulates the proliferation of early haematopoietic cells.Flt3L exists in both a membrane-bound and proteolytically cleaved soluble isoform, both of which are biologically active, and initiates cell proliferation/ differentiation signalling in co-operation with other colony stimulating factors (CSFs) and interleukins, by binding to and activating the tyrosine kinase receptor Flt3 (FLT3R), expressed highly by hematopoietic progenitor cells and stem cells.|
|Preservative & Stabilisers||Preservative Free|
|Storage||Prior to reconstitution store at +4℃. Following reconstitution store at -20℃.|
|Precautions||Anti-Human Flt3 Ligand Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
1. Graddis T. J. et al. (1998) Structure-function analysis of FLT3 Ligand – FLT3 Receptor interactions using a rapid functional screen. J. Biol. Chem. 273: 17626-17633.2. Wodnar-Filipowicz, A. et al. (1996) Flt3 Ligand level reflects hematopoietic progenitor cell function in aplastic anemia and chemotherapy-induced bone marrow aplasia. Blood. 88: 4493-4499.
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