|Application ||WB, E, Func|
|Calculated MW||10625 Da|
|Purification||Antisera to human MDC were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG prepared by affinity chromatography.|
|Immunogen||Recombinant human MDC.|
|Shelf Life||12 months from date of reconstitution.|
|Other Names||C-C motif chemokine 22, CC chemokine STCP-1, MDC(1-69), Macrophage-derived chemokine, Small-inducible cytokine A22, Stimulated T-cell chemotactic protein 1, MDC(3-69), MDC(5-69), MDC(7-69), CCL22, MDC, SCYA22|
|Target/Specificity||Rabbit anti-Human MDC antibody recognizes human MDC, also known as macrophage-derived cytokine, CCL22, CC chemokine STCP-1, Small-inducible cytokine A22 or Stimulated T-cell chemotactic protein 1. MDC is a 93 amino acid, ~10.6 kDa member of the CC chemokine family expressed by macrophages, monocyte-derived dendritic cells, epithelial cells, fibroblasts and highly expressed in the thymus. MDC acts as a chemoattractant for monocytes, dendritic cells, activated T lymphocytes and NK cells, through binding to chemokine (C-C motif) receptor 4 (CCR4). CCR4 is selectively expressed by Th2 cells and several studies have revealed a link between MDC and another ligand of CCR4, known as activation-regulated chemokine (TARC/CCL17), with Th2-mediated inflammatory disorders such as atopic dermatitis and ulcerative colitis (Judge et al.2001).|
|Preservative & Stabilisers||Preservative Free|
|Storage||Prior to reconstitution store at +4℃. Following reconstitution store at -20℃.|
|Precautions||Anti-Human MDC Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
2. Tsujikawa, T. et al. (2012) Autocrine and paracrine loops between cancer cells and macrophages promote lymph node metastasis via CCR4/CCL22 in head and neck squamous cell carcinoma.Int J Cancer. Nov 26. [Epub ahead of print]1. Imai, T. et al. (1998) Macrophage-derived chemokine is a functional ligand for the CC chemokine receptor 4*. J. Biol. Chem. 273: 1764-1768.
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