|Application ||WB, IHC-P, E, Func|
|Calculated MW||7038 Da|
|Purification||Purified IgG was prepared by affinity chromatography.|
|Immunogen||Recombinant human Defensin beta-2(PHP161).|
|Shelf Life||12 months from date of reconstitution.|
|Other Names||Beta-defensin 4A, Beta-defensin 2, BD-2, hBD-2, Defensin, beta 2, Skin-antimicrobial peptide 1, SAP1, DEFB4A, DEFB102, DEFB2, DEFB4|
|Target/Specificity||Goat anti-Human Defensin beta 2 polyclonal antibody recognizes human Defensin beta-2 (BD-2), a ~4.3kDa cationic antimicrobial peptide, also known as Beta-defensin 4A or Skin-antimicrobial peptide 1 (SAP-1) expressed primarily by epithelial cells of the respiratory tract and skin, and an important component of the innate immune response against microbial infections.Expression of BD-2 is induced during inflammation in response to bacterial products and cytokines, and is initially expressed in a precursor form, which is cleaved to release the C-Terminal active portion of the protein which is secreted by the neutrophil and binds to bacterial membranes causing their disruption.|
|Preservative & Stabilisers||Preservative Free|
|Storage||Prior to reconstitution store at +4℃. Following reconstitution store at -20℃.|
|Precautions||Anti-Human Defensin beta 2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
3. Crack, L.R. et al. (2012) Human antimicrobial peptides LL-37 and human ß-defensin-2 reduce viral replication in keratinocytes infected with varicella zoster virusClin Exp Dermatol. 37: 534-43.1. Bals, R. et al. (1998) Human β-Defensin 2 is a salt-sensitive peptide antibiotic expressed in human lung. J. Clin. Invest. 102: 874-880.2. Harder, J. et al. (2000) Mucoid Pseudomonas aeruginosa, TNF-α, and IL-1β, but not IL-6, induce human β-Defensin-2 in respiratory epithelia.Am. J. Respir. Cell Mol. Biol. 22: 714-721.
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