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>   home   >   Products   >   Primary Antibodies   >   Stem Cells   >   Anti-Human CD62L Antibody, clone FMC46 (RPE)   

Anti-Human CD62L Antibody, clone FMC46 (FITC)

Mouse Anti-Human Monoclonal Antibody

  • FC - Anti-Human CD62L Antibody, clone FMC46 (FITC) ABD12015
    Staining of human peripheral blood granulocytes with Mouse anti Human CD62L:FITC
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P14151
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype IgG2b
Clone Names FMC46
Calculated MW 42187 Da
Additional Information
Other Species B,Cynomolgus Pr,Rh,Dog
Purification Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant.
Immunogen PHA stimulated lymphoblasts.
Shelf Life 18 months from date of despatch.
Gene ID 6402
Other Names L-selectin, CD62 antigen-like family member L, Leukocyte adhesion molecule 1, LAM-1, Leukocyte surface antigen Leu-8, Leukocyte-endothelial cell adhesion molecule 1, LECAM1, Lymph node homing receptor, TQ1, gp90-MEL, CD62L, SELL, LNHR, LYAM1
Target/Specificity Mouse anti-Human CD62L antibody, clone FMC46 recognizes human CD62L, also known a L-selectin, a 74-95kDa member of the selectin family of adhesion receptors, which acts as a ligand for both CD62-P (P-selectin) and CD62E (E-selectin). Human CD62L is constitutively expressed on most leucocytes including monocytes, granulocytes, lymphocytes, NK cells, bone marrow myeloid progenitor cells and on a subset of thymocytes.CD62L plays an important role in leucocyte tethering and rolling on the endothelial cell surface and for the homing of naïve lymphocytes to lymph nodes and Peyers patches via HEV. Neutrophils require a constant supply of this molecule on the cell surface for migration into peripheral tissues and adhesion to activated endothelium at sites of inflammation, where CD62L is rapidly shed as soluble L-selectin, but surface expression still remains. The expression of CD62L is down regulated on lymphocytes and neutrophils by PMA stimulation.
Preservative & Stabilisers 0.09% Sodium Azide (NaN3); 1% Bovine Serum Albumin
Storage Store at +4℃ or -20℃.
PrecautionsAnti-Human CD62L Antibody, clone FMC46 (FITC) is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
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1. Pilarski, L. M. et al. (1991) FMC46, a cell protrusion-associated leucocyte adhesion molecule-1 epitope on human lymphocytes and thymocytes.
J. Immunol. 147: 136-143. 2. Zola, H. et al. (1991) The expression of sub-population markers on B cells: A re-evaluation using high sensitivity fluorescence flow cytometry.
Dis. Markers 9: 103-118. 3. Sopp, P. & Howard, C. C. (1997) Cross-reactivity of monoclonal antibodies to defined human leucocyte diferentiation antigens with bovine cells.
Vet. Immunol. Immunopathol. 56: 11-25. 4. Yoshino, N. et al. (2000) Upgrading of flow cytometric analysis for absolute counts, cytokines and other antigenic molecules of Cynomolgus monkeys (Macaca fascicularis) by using anti-human cross-reactive antibodies.
Exp. Anim. 49: 97-110. 5. Haanstra, K.G. et al. (2008) Characterization of naturally occurring CD4+CD25+ regulatory T cells in rhesus monkeys.
Transplantation. 85:1185-92. 6. Dalli, J. et al. (2008) Annexin 1 mediates the rapid anti-inflammatory effects of neutrophil-derived microparticles.
Blood. 112: 2512-2519 7. Raposo, R.A. et al. (2011) Protein Kinase C and NF-{kappa}B-Dependent CD4 Downregulation in Macrophages Induced by T Cell-Derived Soluble Factors: Consequences for HIV-1 Infection.
J Immunol. 187: 748-59. 8. Hughes, S.F. et al. (2010) Total hip and knee replacement surgery results in changes in leukocyte and endothelial markers.
J Inflamm (Lond). 7:2. 9. Bismarck, D. et al. (2012) Canine CD4+CD8+ double positive T cells in peripheral blood have features of activated T cells.
Vet Immunol Immunopathol. 149: 157-66.

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Cat# ABD12015
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