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>   home   >   Products   >   Primary Antibodies   >   Immunology   >   Anti-Mouse CD8 Antibody, clone YTS105.18    

Anti-Mouse CD8 Antibody, clone YTS105.18

Rat Anti-Mouse Monoclonal Antibody

  • FC - Anti-Mouse CD8 Antibody, clone YTS105.18  ABD12025
    Published customer image:NKG2D-dependent infiltration of CD8+T cells into tumors. Tumors were collected from mice that had received one of the four standard treatments: control DNA, Dox plus control DNA, IL-12, Dox plus IL-12 (n = 3 per treatment group). (A) Infiltration of NKG2D-positive cells into tumors. Northern blot analysis was performed to detect NKG2D expression in tumors. Ribosomal RNA was used to confirm equal loading among samples. (B) NKG2D/CD8–positive cells in tumor sections by treatment received. Frozen tumor sections were stained with biotin anti-mouse NKG2D, anti-mouse CD8, or corresponding isotype control antibodies, then with streptavidin-conjugated Alexa fluor 594 or Alexa fluor 488 secondary antibodies. Data shown are representative of three independent experiments. The scale bar is equivalent to 100 µm.From: CD8+T cell-specific induction of NKG2D receptor by doxorubicin plus interleukin-12 and its contribution to CD8+T cell accumulation in tumors. Hu J, Zhu S, Xia X, Zhang L, Kleinerman ES, Li S. Mol Cancer. 2014 Feb 24;13:34.
  • IF - Anti-Mouse CD8 Antibody, clone YTS105.18  ABD12025
    Immunofluorescence staining of a mouse lymph node cryosection with Rat anti mouse CD19, clone 6D5 , green in A and Rat anti Mouse CD8 , red in B. Merged image in C wih nuclei counterstained blue using DAPI. Low power
  • FC - Anti-Mouse CD8 Antibody, clone YTS105.18  ABD12025
    Staining of mouse spleen cells with Rat anti Mouse CD8
  • IHC-P - Anti-Mouse CD8 Antibody, clone YTS105.18  ABD12025
    Immunoperoxidase staining of Mouse lymph node cryosection using Rat anti Mouse CD8α antibody followed by horseradish peroxidase conjugated Goat anti Rat IgG for detection. Low power
  • IF - Anti-Mouse CD8 Antibody, clone YTS105.18  ABD12025
    Immunofluorescence staining of mouse lymph node cryosection using Rat anti Mouse CD11b antibody , green in A and Rat anti Mouse CD8 antibody , red in B, Merged image in C
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P01731
Reactivity Mouse
Host Rat
Clonality Monoclonal
Isotype IgG2a
Clone Names YTS105.18
Calculated MW 27456 Da
Additional Information
Purification Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatent.
Immunogen Mouse spleen cells.
Shelf Life 18 months from date of despatch.
Gene ID 12525
Other Names T-cell surface glycoprotein CD8 alpha chain, T-cell surface glycoprotein Lyt-2, CD8a, Cd8a, Lyt-2, Lyt2
Target/Specificity Rat anti-Mouse CD8, clone YTS105.18 recognizes a non polymorphic epitope on the mouse CD8 alpha chain. This antibody has been reported to block MHC I dependent T cell responses in vitroandin vivo, and induces transplantation tolerance in combination with CD4 antibodies (Cobboldet al.1990&Wiseet al.1998).
Preservative & Stabilisers Preservative Free
Storage Store at -20℃ only.
PrecautionsAnti-Mouse CD8 Antibody, clone YTS105.18 is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
Citations (0)

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1. Qin, S. et al. (1990) Induction of tolerance in peripheral T cells with monoclonal antibodies.
Eur. J. Immunol. 20: 2737-2745. 2. Cobbold, S.P. et al. (1990) The induction of skin graft tolerance in MHC-mis matched or primed recipients: primed T-cells can be tolerized in the periphery with CD4 and CD8 antibodies.
Eur. J. Immunol. 20: 2747-2755. 3. Wise, M.P. et al. (1998) Cutting edge: Linked suppression of skin graft rejection can operate through indirect recognition.
J. Immunol. 161: 5813-5816. 4. Lacroix-Lamande, S. et al. (2009) Neonate intestinal immune response to CpG oligodeoxynucleotide stimulation.
PLoS One. 4: 1-8. 5. Auray, G. et al. (2007) Involvement of intestinal epithelial cells in dendritic cell recruitment during C. parvum infection
Microbes Infect. 9: 574-82. 6. Sroga, J.M. et al. (2003) Rats and mice exhibit distinct inflammatory reactions after spinal cord injury.
J Comp Neurol. 462: 223-40. 7. Karlsson, M.R. et al. (2010) Hypersensitivity and oral tolerance in the absence of a secretory immune system.
Allergy. 65: 561-70. 8. Himoudi, N. et al. (2007) Development of anti-PAX3 immune responses; a target for cancer immunotherapy
Cancer Immunol Immunother. 56: 1381-95. 9. Nakashima, H. et al. (2011) A Novel Combination Immunotherapy for Cancer by IL-13Ra2-Targeted DNA Vaccine and Immunotoxin in Murine Tumor Models.
J Immunol. 187: 4935-46.

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Cat# ABD12025
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