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>   home   >   Products   >   Primary Antibodies   >   Immunology   >   Anti-Human CD16 Antibody, clone LNK16 (FITC)   

Anti-Human CD16 Antibody, clone LNK16

Mouse Anti-Human Monoclonal Antibody

  • FC - Anti-Human CD16 Antibody, clone LNK16  ABD12032
    Staining of human peripheral blood granulocytes with Mouse anti Human CD16:Biotin
  • FC - Anti-Human CD16 Antibody, clone LNK16  ABD12032
    Staining of human peripheral blood lymphocytes with Mouse anti Human CD16: Low Endotoxin
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession O75015
Other Accession P08637
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype IgG1
Clone Names LNK16
Calculated MW 26216 Da
Additional Information
Purification Purified IgG prepared by ion exchange chromatography
Immunogen Normal human peripheral blood granulocytes.
Shelf Life 18 months from date of despatch.
Gene ID 2215
Other Names Low affinity immunoglobulin gamma Fc region receptor III-B, Fc-gamma RIII-beta, Fc-gamma RIII, Fc-gamma RIIIb, FcRIII, FcRIIIb, FcR-10, IgG Fc receptor III-1, CD16b, FCGR3B, CD16B, FCG3, FCGR3, IGFR3
Target/Specificity Mouse anti-Human CD16 antibody, clone LNK16 recognizes CD16, a 50-65 kDa cell surface molecule which exists in two forms - a transmembranous form expressed by NK cells and some T cells, and a phosphatidylinositol linked form expressed by granulocytes.CD16 is a low affinity receptor for IgG (FcR III), and is an important receptor mediating ADCC by NK cells. Mouse anti-Human CD16 antibody, clone LNK16 has been reported to block the binding of IgG to the CD16 molecule (Tamm and Schmidt 1996).
Preservative & Stabilisers 0.09% Sodium Azide
Storage Store at +4℃ or at -20 ℃.
PrecautionsAnti-Human CD16 Antibody, clone LNK16 is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
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1. Tamm, A. & Schmidt, R.E. (1996) The binding epitopes of human CD16 (Fc gamma RIII) monoclonal antibodies. Implications for ligand binding.
J Immunol. 157 (4): 1576-81. 2. Fleit, H.B. et al. (1982) Human neutrophil Fc gamma receptor distribution and structure.
Proc Natl Acad Sci U S A. 79 (10): 3275-9. 3. van de Winkel, J.G. & Capel, P.J. (1993) Human IgG Fc receptor heterogeneity: molecular aspects and clinical implications.
Immunol Today. 14 (5): 215-21. 4. Pillay, J. et al. (2012) A subset of neutrophils in human systemic inflammation inhibits T cell responses through Mac-1.
J Clin Invest. 122: 327-36. 5. Morris, D.L. et al. (2010) Evidence for both copy number and allelic (NA1/NA2) risk at the FCGR3B locus in systemic lupus erythematosus.
Eur J Hum Genet. 18 (9): 1027-31. 6. Kamp, V.M. et al. (2012) Human suppressive neutrophils CD16bright/CD62Ldim exhibit decreased adhesion.
J Leukoc Biol. 92 (5): 1011-20. 7. Hanna, J. et al. (2003) CXCL12 expression by invasive trophoblasts induces the specific migration of CD16- human natural killer cells.
Blood. 102:1569-77. 8. Moalli, F. et al. (2010) Role of complement and Fc{gamma} receptors in the protective activity of the long pentraxin PTX3 against Aspergillus fumigatus.
Blood. 116: 5170-80. 9. Armour, K.L. et al. (2010) Expression of human FcgammaRIIIa as a GPI-linked molecule on CHO cells to enable measurement of human IgG binding.
J Immunol Methods. 354: 20-33. 10. Welters, I.D. et al. (2010) Ketamine inhibits transcription factors activator protein 1 and nuclear factor-kappaB, interleukin-8 production, as well as CD11b and CD16 expression: studies in human leukocytes and leukocytic cell lines.
Anesth Analg. 110: 934-41. 11. Bowles, J.A. et al. (2006) Anti-CD20 monoclonal antibody with enhanced affinity for CD16 activates NK cells at lower concentrations and more effectively than rituximab.
Blood. 108: 2648-54. 12. Meknache, N. et al. (2009) Human basophils express the glycosylphosphatidylinositol-anchored low-affinity IgG receptor FcgammaRIIIB (CD16B).
J Immunol. 182: 2542-50. 13. Lee, S.F. et al. (1999) Cytokine receptor common beta chain as a potential activator of cytokine withdrawal-induced apoptosis.
Mol Cell Biol. 19: 7399-409. 14. Sironi, M. et al. (2006) Differential regulation of chemokine production by Fcgamma receptor engagement in human monocytes: association of CCL1 with a distinct form of M2 monocyte activation (M2b, Type 2).
J Leukoc Biol. 80: 342-9. 15. Weissmüller, S. et al. (2012) ICOS-LICOS interaction is critically involved in TGN1412-mediated T-cell activation.
Blood. 119: 6268-77. 16. Kahn, F. et al. (2008) Antibodies against a surface protein of Streptococcus pyogenes promote a pathological inflammatory response.
PLoS Pathog. 4: e1000149.1. Ravetch, J.V. & Kinet, J.P. (1991) Fc receptors.
Annu Rev Immunol. 9: 457-92.

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Cat# ABD12032
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