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>   home   >   Products   >   Primary Antibodies   >   Stem Cells   >   CD79a Antibody, clone ZL7-4 (Monoclonal Antibody) (FITC)   

CD79a Antibody, clone ZL7-4 (Monoclonal Antibody)

Mouse Anti-Human Monoclonal Antibody

  • FC - CD79a Antibody, clone ZL7-4 (Monoclonal Antibody)  ABD12051
    Staining of RAMOS cells with Mouse anti Human CD79a: Alexa Fluor® 488
  • FC - CD79a Antibody, clone ZL7-4 (Monoclonal Antibody)  ABD12051
    Staining of RAMOS cells with Mouse anti Human CD79a:FITC
  • FC - CD79a Antibody, clone ZL7-4 (Monoclonal Antibody)  ABD12051
    Staining of human peripheral blood lymphocytes with Mouse anti Human CD79a: Alexa Fluor® 647
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P11912
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype IgG1
Clone Names ZL7-4
Calculated MW 25038 Da
Additional Information
Purification Purified IgG prepared by affinity chromatography on Protein A
Immunogen IgM complex isolated from Daudi cells
Shelf Life 18 months from date of despatch.
Gene ID 973
Other Names B-cell antigen receptor complex-associated protein alpha chain, Ig-alpha, MB-1 membrane glycoprotein, Membrane-bound immunoglobulin-associated protein, Surface IgM-associated protein, CD79a, CD79A, IGA, MB1
Target/Specificity Mouse anti-Human CD79a antibody, clone ZL7-4 recognizes  the human B-cell antigen receptor complex-associated protein alpha chain, also known as MB-1 membrane glycoprotein or CD79a. clone ZL7-4 reacts with CD79a positive cells by flow cytometry and with CD79a in an ELISA specific for a fusion protein of CD79a-Fc.Mouse anti-Human CD79a antibody, clone ZL7-4 has been reported to be useful in distinguishing B-CLL from mantle cell lymphoma in flow cytometric assays (Bellet al.1999).Mouse anti-Human CD79a antibody, clone ZL7-4 has been reported to be suitable for Immunohistochemistry on frozen and pre-treated paraffin sections, but does exhibit epithelial staining.Mouse anti-Human CD79a antibody, clone ZL7-4 has been reported to induce phosphorylation of syk kinase  (Lanhamet al.2003).
Preservative & Stabilisers 0.09% Sodium Azide
Storage Store at +4℃ or at -20 ℃.
PrecautionsCD79a Antibody, clone ZL7-4 (Monoclonal Antibody) is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
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1. Zhang. L. et al. (1995) The development of anti-CD79 monoclonal antibodies for treatment of B-cell neoplastic disease.
Therapeutic Immunology 2:191-202 2. Bell, P.B. et al. (1999) CD79a detected by ZL7.4 separates chronic lymphocytic leukemia from mantle cell lymphoma in the leukemic phase
Cytometry (Comm. Clin. Cytometry) 38: 102 - 105. 3. Lanham, S. et al. (2003) Differential signaling via surface IgM is associated with VH gene mutational status and CD38 expression in chronic lymphocytic leukemia
Blood. 101: 1087 - 1093. 4. Vendel,A.C. et al (2009) B and T lymphocyte attenuator regulates B cell receptor signaling by targeting Syk and BLNK
J Immunol. 182: 1509-17. 5. Allsup, D.J. et al. (2005) B-cell receptor translocation to lipid rafts and associated signaling differ between prognostically important subgroups of chronic lymphocytic leukemia.
Cancer Res. 65: 7328-37. 6. Cragg, M.S. et al. (2002) The alternative transcript of CD79b is overexpressed in B-CLL and inhibits signaling for apoptosis.
Blood. 100: 3068-76. 7. Rahemtullah, A. et al. (2008) CD20+ T-cell lymphoma: clinicopathologic analysis of 9 cases and a review of the literature.
Am J Surg Pathol. 32 (11): 1593-607.

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Cat# ABD12051
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