|Application ||WB, IHC-F, E|
|Calculated MW||17918 Da|
|Purification||Purified IgG prepared by affinity chromatography on Protein A from tissue culture supernatant|
|Immunogen||Recombinant rat IFN gamma|
|Shelf Life||18 months from date of despatch.|
|Other Names||Interferon gamma, IFN-gamma, Ifng|
|Target/Specificity||Mouse anti-Rat Interferon gamma antibody, clone DB-1 reacts with both mouse and rat Interferon gamma. Clone DB-1 exhibits high affinity binding to the natural and recombinant forms and effectively neutralizes the anti-viral activity of IFN-gamma. It also blocks the induction of Ia antigen expression on murine keratinocytes.Mouse anti-Rat Interferon gamma antibody, clone DB-1 does not cross-react with rodent IFN-alpha or IFN-beta or with human interferons.Mouse anti-Rat Interferon gamma antibody, clone DB-1 has also been reported for use in neutralising studies.|
|Preservative & Stabilisers||0.09% Sodium Azide|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Rat Interferon gamma Antibody, clone DB-1 is for research use only and not for use in diagnostic or therapeutic procedures.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
1. Paineau, J. et al. (1991) Effect of recombinant interferon gamma and interleukin-2 and of a monoclonal antibody against interferon gamma on the rat immune response against heart allografts.J. Heart Lung Transplant. 10: 424-430. 2. Paineau, J. et al.. (1989) Effects of gamma interferon and interleukin-2, and of gamma-interferon antibodies, on the rat immune response against allografts.Transplant Proc. 21: 999-1001. 3. Van der Meide, P.H. et al. (1986) The purification and characterization of rat gamma interferon by use of two monoclonal antibodies.J. Gen. Virol. 67: 1059-1071. 4. Keller, R. et al. (1987) Induction, maintenance, and reinduction of tumoricidal activity in bone marrow-derived mononuclear phagocytes by Corynebacterium parvum. Evidence for the involvement of a T cell- and interferon-gamma-independent pathway of macrophage activation.J. Immunol. 138: 2366-12371. 5. Jacob, C.O. et al. (1989) Heterogeneous effects of IFN-gamma in adjuvant arthritis.J. Immunol. 142: 1500-1505. 6. Kingston, A.E. et al. (1989) Schwann cells co-cultured with stimulated T cells and antigen express major histocompatibility complex (MHC) class II determinants without interferon-gamma pretreatment: synergistic effects of interferon-gamma and tumor necrosis factor on MHC class II induction.Eur. J. Immunol. 19: 177-183. 7. Graf, M. et al. (2001) IL-6 secretion by a rat T9 Glioma clone induces a neutrophil-dependent antitumor response with resultant cellular, antiglioma immunity. J. Immunol. 166: 121 - 129. 8. Elflein, K. et al. (2003) Rapid recovery from T lymphopenia by CD28 superagonist therapy.Blood. 102: 1764-70. 9. Straube, F. and Herrmann, T. (2001) Differential modulation of CD8beta by rat gammadelta and alphabeta T cells after activation.Immunology. 104: 252-8. 10. van der Meide PH et al. (1989) Isolation and characterization of monoclonal antibodies directed to rat interferon-gamma.Lymphokine Res. 8 (4): 439-49.
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