|Application ||IHC-F, IF, FC, IP|
|Calculated MW||129151 Da|
|Purification||Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant.|
|Immunogen||Mouse spleen dendritic cells.|
|Shelf Life||18 months from date of despatch.|
|Other Names||Integrin alpha-X, CD11 antigen-like family member C, Leukocyte adhesion glycoprotein p150, 95 alpha chain, Leukocyte adhesion receptor p150, 95, CD11c, Itgax|
|Target/Specificity||Hamster anti-Mouse CD11c antibody, clone N418 recognizes the murine homolog of human CD11c, a 150/90 kDa member of the beta 2 integrin family. In mice, CD11c is primarily expressed by dendritic cells.Hamster anti-Mouse CD11c antibody, clone N418 has been reported to enhance antigen specific responses when used to target dendritic cells in vivo(Wanget al.2000).|
|Preservative & Stabilisers||0.09% Sodium Azide|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Mouse CD11c Antibody, clone N418 is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
1. Crowley, M.T. et al. (1990) Use of the fluorescence activated cell sorter to enrich dendritic cells from mouse spleen.J Immunol Methods. 133 (1): 55-66. 2. Metlay, J.P. et al. (1990) The distinct leukocyte integrins of mouse spleen dendritic cells as identified with new hamster monoclonal antibodies.J Exp Med. 171 (5): 1753-71. 3. Wang, H. et al. (2000) Rapid antibody responses by low-dose, single-step, dendritic cell-targeted immunization.Proc Natl Acad Sci U S A. 97 (2): 847-52. 4. Lundqvist, J. et al. (2010) Concomitant infection decreases the malaria burden but escalates relapsing fever borreliosis.Infect Immun. 78 (5): 1924-30. 5. Beyer, M. et al. (2005) The beta2 integrin CD11c distinguishes a subset of cytotoxic pulmonary T cells with potent antiviral effects in vitro and in vivo.Respir Res. 6: 70. 6. Goupil, M. et al. (2009) Macrophage-mediated responses to Candida albicans in mice expressing the human immunodeficiency virus type 1 transgene.Infect Immun. 77: 4136-49. 7. Linehan, S.A.. (2005) The mannose receptor is expressed by subsets of APC in non-lymphoid organs.BMC Immunol. 6:4. 8. Bjorck, P. (2004) Dendritic cells exposed to herpes simplex virus in vivo do not produce IFN-alpha after rechallenge with virus in vitro and exhibit decreased T cell alloreactivity.J Immunol. 172: 5396-404. 9. Dahlen, E. et al. (1998) Dendritic cells and macrophages are the first and major producers of TNF-alpha in pancreatic islets in the nonobese diabetic mouse.J Immunol. 160: 3585-93. 10. de Jersey, J. et al. (2002) Activation of CD8 T cells by antigen expressed in the pituitary gland.J Immunol. 169: 6753-9. 11. Dimier-Poisson, I. et al. (2003) Protective mucosal Th2 immune response against Toxoplasma gondii by murine mesenteric lymph node dendritic cells.Infect Immun. 71: 5254-65. 12. Gonzalez-Juarrero, M. and Orme, I.M. (2001) Characterization of murine lung dendritic cells infected with Mycobacterium tuberculosis.Infect Immun. 69: 1127-33. 13. Hamada, H. et al. (2002) Identification of multiple isolated lymphoid follicles on the antimesenteric wall of the mouse small intestine.J Immunol. 168: 57-64. 14. Meng, Q. et al. (2007) Phenotypes, distribution, and morphological features of antigen-presenting cells in the murine cornea following intravitreal injection.Mol Vis. 13: 475-86. 15. Mercier, S. et al. (2002) Distinct roles of adenovirus vector-transduced dendritic cells, myoblasts, and endothelial cells in mediating an immune response against a transgene product.J Virol. 76: 2899-911. 16. Moos, M.P. et al. (2005) The lamina adventitia is the major site of immune cell accumulation in standard chow-fed apolipoprotein E-deficient miceArterioscler Thromb Vasc Biol. 25: 2386-91. 17. Nunez, R. et al. (1999) Immortalized cell lines derived from mice lacking both type I and type II IFN receptors unify some functions of immature and mature dendritic cells.Immunol Cell Biol. 77: 153-63. 18. Ponce, L.V. et al. (2005) Adoptive transfer of dendritic cells modulates immunogenesis and tolerogenesis in a neonatal model of murine cutaneous leishmaniasis.Kinetoplastid Biol Dis. 4: 2. 19. Zhang, L. et al. (2011) The inflammatory changes of adipose tissue in late pregnant mice.J Mol Endocrinol. 47 (2): 157-65. 20. Donaldson, D.S. et al. (2012) M cell-depletion blocks oral prion disease pathogenesis.Mucosal Immunol. 5: 216-25. 21. Wada, T. et al. (2013) Eplerenone ameliorates the phenotypes of metabolic syndrome with NASH in liver-specific SREBP-1c Tg mice fed high-fat and high-fructose diet.Am J Physiol Endocrinol Metab. 305 (11): E1415-25. 22. Kayser, B.D. et al. (2015) Perinatal Overnutrition Exacerbates Adipose Tissue Inflammation Caused by High-Fat Feeding in C57BL/6J Mice.PLoS One. 10 (3): e0121954. 23. Kan, M.J. et al. (2015) Arginine deprivation and immune suppression in a mouse model of Alzheimer's disease.J Neurosci. 35 (15): 5969-82.
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