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>   home   >   Products   >   Primary Antibodies   >   Anti-Rat CD71 Antibody, clone OX-26 (RPE)   

Anti-Rat CD71 Antibody, clone OX-26 (Biotin)

Mouse Anti-Rat Monoclonal Antibody

  • FC - Anti-Rat CD71 Antibody, clone OX-26 (Biotin) ABD12083
    Staining of mouse spleen cells with Mouse anti Rat CD71:Low Endotoxin
  • FC - Anti-Rat CD71 Antibody, clone OX-26 (Biotin) ABD12083
    Staining of mouse spleen with Mouse anti Rat CD71:Biotin
  • FC - Anti-Rat CD71 Antibody, clone OX-26 (Biotin) ABD12083
    Staining of rat spleen cells with Mouse anti Rat CD71:RPE
  • FC - Anti-Rat CD71 Antibody, clone OX-26 (Biotin) ABD12083
    Staining of rat spleen lymphocytes with Mouse anti Rat CD71
  • FC - Anti-Rat CD71 Antibody, clone OX-26 (Biotin) ABD12083
    Published customer image:FITC conjugated Mouse anti Rat CD71 antibody, clone OX-26 used for flow cytometryImage caption:Flow cytometric analysis of follicle stem cells separated by Vario MACS. (a–d) Single-color flow cytometric analysis of the selected follicle stem cells. X axis represents fluorescence intensity, and Y axis represents cell number. (a) Bulge region cell suspension without antibody staining was used as control. (b) CD34bri cells were isolated by Vario MACS. (c) Control for a6 separation. (d) a6bri cells were isolated by Vario MACS. (e–h) Two-color flow cytometric analysis of follicle stem cells selected by Vario MACS. Cells were divided into four subpopulations: a PEbri FITCdim cells; b PEbri FITCbri cells; c PEdim FITCdim cells; and d PEdim FITCbri cells. (e) Control. (f) CD71 and CD34 was detected with FITC (X axis) and with PE (Y axis). The majority of the isolated cells were CD34briCD71dim cells, characterized by high level expression of CD34 and low level of CD71. No CD34dimCD71bri cells were detected in our experiments. (g) Control for a6 and CD71 combined separation; (h) The a6briCD71dim cells were the main subpopulation of the separated cells.From: Huang E, Lian X, Chen W, Yang T, Yang L. Characterization of rat hair follicle stem cells selected by vario magnetic activated cell sorting system. Acta Histochem Cytochem. 2009 Oct 30;42(5):129-36.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q99376
Reactivity Rat
Host Mouse
Clonality Monoclonal
Isotype IgG2a
Clone Names OX-26
Calculated MW 70153 Da
Additional Information
Purification Purified IgG prepared by affinity chromatography on Protein G
Immunogen PHA activated rat lymphocytes.
Shelf Life 18 months from date of despatch.
Other Names Transferrin receptor protein 1, TR, TfR, TfR1, Trfr, CD71, Tfrc, Trfr
Target/Specificity Mouse anti-Rat CD71 antibody, clone OX-26 recognizes rat CD71, also known as transferrin receptor, a homodimeric type II transmembrane protein, expressed by all proliferating cells and cells with a requirement for iron, including reticulocytes and capillary endothelium in brain. Clone 0X-26 also binds to a number of non-dividing normal tissues.The balance between a sufficient amount of iron uptake and prevention of accumulation of excess iron within a cell, is vitally important to maintain cellular functions such as oxygen and electron transport and mitochondrial energy metabolism, whilst preventing permanent cell and tissue damage. Transferrin receptor (CD71), transferrin and ferritin have been identified as specialised proteins which control the uptake, transport and storage of free iron in tissues, thereby maintaining iron homeostasis (Crihtonet al.1992).An imbalance in iron homeostasis within the brain has been linked with the neurodegenerative diseases, Alzheimer’s, Parkinson’s, Huntington’s and Multiple Sclerosis (Benarroch 2009).Mouse anti-rat CD71 clone OX-26 is reported as suitable for use in immunoelectron microscopy (Lipardiet al.2002). OX-26 detects a band of ~95kDa in Western blotting under reducing conditions and ~195kDa under non-reducing conditions reflecting it's homodimeric structure.
Preservative & Stabilisers 0.09% Sodium Azide; 1% Bovine Serum Albumin
Storage Store at +4℃ or at -20 ℃.
PrecautionsAnti-Rat CD71 Antibody, clone OX-26 (Biotin) is for research use only and not for use in diagnostic or therapeutic procedures.
Citations (0)

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1. Jefferies, W.A. et al. (1985) Analysis of lymphopoietic stem cells with a monoclonal antibody to the rat transferrin receptor.
Immunology 54: 333-341. 2. Yefimova, M.G. et al. (1984) Impaired retinal iron homeostasis associated with defective phagocytosis in Royal College of Surgeons rats.
Inv. Opth. & Vis. Sci. 43: 537-545. 3. Jefferies, W.A. et al. (1984) Transferrin receptor on endothelium of brain capillaries.
Nature 312: 162-163. 4. Lipardi, C. et al. (2002) Differential recognition of a tyrosine-dependent signal in the basolateral and endocytic pathways of thyroid epithelial cells.
Endocrinology. 143: 1291-1301. 5. Stevenson, K.S. et al. (2009) Isolation, characterization, and differentiation of thy1.1-sorted pancreaticadult progenitor cell populations.
Stem Cells Dev. 18: 1389-98. 6. Jung, S.H. et al. (2008) Plantaris muscle of aged rats demonstrates iron accumulation and altered expression of iron regulation proteins.
Exp Physiol. 93: 407-14. 7. Chen, X. et al. (2000) Oxidative damage in an esophageal adenocarcinoma model with rats.
Carcinogenesis. 21: 257-63. 8. Huang, E. et al. (2009) Characterization of rat hair follicle stem cells selected by vario magnetic activated cell sorting system.
Acta Histochem Cytochem. 42: 129-36. 9. Petrusca, D.N. et al. (2010) Sphingolipid-mediated inhibition of apoptotic cell clearance by alveolar macrophages.
J Biol Chem. 285: 40322-32. 10. Wu, Y.J. et al. (2007) In vivo leukocyte labeling with intravenous ferumoxides/protamine sulfate complex and in vitro characterization for cellular magnetic resonance imaging.
Am J Physiol Cell Physiol. 293: C1698-708. 11. Yefimova M.G. et al. (2002) Impaired retinal iron homeostasis associated with defective phagocytosis in Royal College of Surgeons rats.
Invest Ophthalmol Vis Sci. 43: 537-45. 12. Gosk, S. et al. (2004) Targeting anti-transferrin receptor antibody (OX26) and OX26-conjugated liposomes to brain capillary endothelial cells using in situ perfusion.
J Cereb Blood Flow Metab. 24: 1193-204. 13. Pang, Z. (2008) Preparation and brain delivery property of biodegradable polymersomes conjugated with OX26.
J Control Release. 128: 120-7. 14. Moos, T, Morgan, E.H. (2001) Restricted transport of anti-transferrin receptor antibody (OX26) through the blood-brain barrier in the rat.
J Neurochem. 79: 119-29. 15. Moos, T. et al. (2003) Delivery of transferrin and immunoglobulins to the ventricular system of the rat.
Front Biosci. 8: a102-9. 16. Fabriek, B.O. et al. (2007) The macrophage CD163 surface glycoprotein is an erythroblast adhesion receptor.
Blood. 109: 5223-9. 17. Rathnasamy, G. et al. (2011) Iron and Iron Regulatory Proteins in Amoeboid Microglial Cells Are Linked to Oligodendrocyte Death in Hypoxic Neonatal Rat Periventricular White Matter through Production of Proinflammatory Cytokines and Reactive Oxygen/Nitrogen Species
J. Neurosci 31: 17982-95. 18. De Luca, M.A. et al. (2015) Lactoferrin- and antitransferrin-modified liposomes for brain targeting of the NK3 receptor agonist senktide: Preparation and in vivo evaluation.
Int J Pharm. 479: 129-137.

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