|Application ||IHC-F, FC, IP|
|Calculated MW||57825 Da|
|Purification||Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant|
|Shelf Life||18 months from date of despatch.|
|Other Names||Intercellular adhesion molecule 1, ICAM-1, Major group rhinovirus receptor, CD54, ICAM1|
|Target/Specificity||Mouse anti-Human CD54 antibody, clone 15.2 recognizes the human CD54 cell surface antigen, a 90kDa glycoprotein also known as ICAM-1. CD54 is expressed by many cells following activation by inflammatory mediators.Mouse anti-Human CD54 antibody, clone 15.2 is reported to block CD54 function (Berendtet al.1992).|
|Preservative & Stabilisers||0.09% Sodium Azide|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Human CD54 Antibody, clone 15.2 is for research use only and not for use in diagnostic or therapeutic procedures.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
1. Dransfield, I. et al. (1992) Interaction of leukocyte integrins with ligand is necessary but not sufficient for function.J Cell Biol. 116:1527-35. 2. Berendt, A. et al. (1992) The binding site on ICAM-1 for plasmodium falciparum-infected erythrocytes overlaps, but is distinct from, the LFA-1- binding site. Cell. 68: 71-81. 3. Urquhart, P. et al. (2007) Carbon monoxide-releasing molecules modulate leukocyte-endothelial interactions under flow.J Pharmacol Exp Ther 321: 656-662. 4. Baratin, M. et al. (2007) Dissection of the role of PfEMP1 and ICAM-1 in the sensing of Plasmodium-falciparum-infected erythrocytes by natural killer cells.PLos One 2: e228. 5. van Buul, J.D. et al. (2010) Inside-out regulation of ICAM-1 dynamics in TNF-alpha-activated endothelium.PLoS One 5: e11336. 6. Diaz-Romero, J. et al. (2008) Immunophenotypic changes of human articular chondrocytes during monolayer culture reflect bona fide dedifferentiation rather than amplification of progenitor cells.J Cell Physiol. 214: 75-83. 7. Di Lorenzo, A. et al. (2011) Endothelial reticulon-4B (Nogo-B) regulates ICAM-1-mediated leukocyte transmigration and acute inflammation.Blood. 117: 2284-95. 8. Porter, J.C. and Hall, A. (2009) Epithelial ICAM-1 and ICAM-2 regulate the egression of human T cells across the bronchial epithelium.FASEB J. 23: 492-502. 9. Corvaisier, M. et al. (2005) V gamma 9V delta 2 T cell response to colon carcinoma cells.J Immunol. 175: 5481-8. 10. Horrocks, P. et al. (2005) PfEMP1 expression is reduced on the surface of knobless Plasmodium falciparum infected erythrocytes.J Cell Sci. 118: 2507-18. 11. Lozanoska-Ochser, B. et al. (2008) Expression of CD86 on human islet endothelial cells facilitates T cell adhesion and migration.J Immunol. 181: 6109-16. 12. Norling, L.V. et al. (2008) Inhibitory control of endothelial galectin-1 on in vitro and in vivo lymphocyte trafficking.FASEB J. 22: 682-90. 13. Baumer, Y. et al. (2011) Telomerase-based immortalization modifies the angiogenic/inflammatory responses of human coronary artery endothelial cells.Exp Biol Med (Maywood). 236: 692-700. 14. Lask, A. et al. (2011) TCR-Independent Killing of B Cell Malignancies by Anti-Third-Party CTLs: The Critical Role of MHC-CD8 Engagement.J Immunol. 2011 Aug 15;187(4):2006-14. 15. Sommaggio, R. et al. (2012) Multiple Receptors Trigger Human NK Cell-Mediated Cytotoxicity against Porcine Chondrocytes.J Immunol. 188: 2075-83. 16. Murphy, A.J. et al. (2013) Anti-inflammatory functions of apolipoprotein a-I and high-density lipoprotein are preserved in trimeric apolipoprotein a-I.J Pharmacol Exp Ther. 344: 41-9.
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