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>   home   >   Products   >   Primary Antibodies   >   Immunology   >   Anti-Human CD89 Antibody, clone MIP8a (RPE)   

Anti-Human CD89 Antibody, clone MIP8a

Mouse Anti-Human Monoclonal Antibody

  • FC - Anti-Human CD89 Antibody, clone MIP8a  ABD12122
    Staining of human peripheral blood granulocytes with Mouse anti Human CD89: RPE
  • FC - Anti-Human CD89 Antibody, clone MIP8a  ABD12122
    Staining of human peripheral blood granulocytes with Mouse anti Human CD89:Low endotoxin
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P24071
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype IgG1
Clone Names MIP8a
Additional Information
Purification Purified IgG prepared by affinity chromatography on Protein A
Immunogen Recombinant soluble human Fc alpha R.
Shelf Life 18 months from date of despatch.
Other Names Immunoglobulin alpha Fc receptor, IgA Fc receptor, CD89, FCAR, CD89
Target/Specificity Mouse anti-Human CD89 antibody, clone MIP8a recognizes the human CD89 cell surface antigen, a 50-75kDa cell surface glycoprotein that is also known as the IgA receptor (Fc alpha R).CD89 is expressed by peripheral blood monocytes and neutrophils.MIP8a blocks binding of IgA to the Fc alpha R, and also inhibits neutrophil phagocytosis of IgA complexes.
Preservative & Stabilisers 0.09% Sodium Azide
Storage Store at +4℃ or at -20 ℃.
PrecautionsAnti-Human CD89 Antibody, clone MIP8a is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
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1. Zhang, W. et al. (2000) Neutrophil lactoferrin release induced by IgA immune complexes differed from that induced by cross-linking of fcalpha receptors (FcalphaR) with a monoclonal antibody, MIP8a.
Clin Exp Immunol. 121 (1): 106-11. 2. Lu, J. et al. (2011) Recognition and functional activation of the human IgA receptor (Fc{alpha}RI) by C-reactive protein.
Proc Natl Acad Sci U S A. 108: 4974-9. 3. Duc, M. et al. (2010) Antigen binding to secretory immunoglobulin A results in decreased sensitivity to intestinal proteases and increased binding to cellular Fc receptors.
J Biol Chem. 285: 953-60. 4. Wu, J. et al. (2007) FcαRI (CD89) alleles determine the proinflammatory potential of serum IgA.
J Immunol. 178: 3973-82. 5. Hamre, R. et al. (2003) Expression and modulation of the human immunoglobulin A Fc receptor (CD89) and the FcR gamma chain on myeloid cells in blood and tissue.
Scand J Immunol. 57: 506-16. 6. Qian,K. et al. (2008) Functional expression of IgA receptor FcalphaRI on human platelets.
J Leukoc Biol. 84: 1492-500. 7. Van Egmond, M. (2011) Method for the treatment or prophylaxis of chronic inflammatory diseases.
European Patent Application No: 12/736963 8. Pascal, V. et al. (2012) Anti-CD20 IgA can protect mice against lymphoma development: evaluation of the direct impact of IgA and cytotoxic effector recruitment on CD20 target cells.
Haematologica. 97 (11): 1686-94. 9. Mladenov, R. et al. (2015) The Fc-alpha receptor is a new target antigen for immunotherapy of myeloid leukemia.
Int J Cancer. 137 (11): 2729-38.

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Cat# ABD12122
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