|Application ||WB, IHC-F, IF, FC|
|Calculated MW||52730 Da|
|Immunogen||CHO cells expressing mouse MARCO|
|Other Names||Macrophage receptor MARCO, Macrophage receptor with collagenous structure, Marco|
|Target/Specificity||Rat anti-Mouse MARCO antibody, clone ED31 recognizes the murine cell surface antigen designated MARCO (Macrophage receptor with collagenous structure), which is a member of the class A scavenger receptor family.MARCO is expressed by distinct populations of macrophages in the spleen and lymph nodes, but is rapidly induced on macrophages in other tissues (e.g. Liver Kupffer cells) during infection or LPS treatment.Rat anti-Mouse MARCO antibody, clone ED31 binds to the C-terminal cysteine rich domain of MARCO, and has been shown to block ligand binding.|
|Precautions||Anti-Mouse MARCO Antibody, clone ED31 (RPE) is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
1. van der Laan, L.J. et al. (1999) Regulation and functional involvement of macrophage scavenger receptor MARCO in clearance of bacteria in vivo.J Immunol. 162 (2): 939-47. 2. van der Laan, L.J. et al. (1997) Macrophage scavenger receptor MARCO: in vitroandin vivo regulation and involvement in the anti-bacterial host defense.Immunol Lett. 57 (1-3): 203-8. 3. Dioszeghy, V. et al. (2008) 12/15-Lipoxygenase regulates the inflammatory response to bacterial products in vivo.J Immunol. 181: 6514-24. 4. Devey, L. et al. (2009) Tissue-resident macrophages protect the liver from ischemia reperfusion injury via a heme oxygenase-1-dependent mechanism.Mol Ther. 17: 65-72. 5. Hsu, K.M. et al. (2009) Murine cytomegalovirus displays selective infection of cells within hours after systemic administration.J Gen Virol. 90: 33-43. 6. Kang, Y.S. et al. (2004) The C-type lectin SIGN-R1 mediates uptake of the capsular polysaccharide of Streptococcus pneumoniae in the marginal zone of mouse spleen.Proc Natl Acad Sci U S A. 101: 215-20. 7. Karlsson, M.C. et al. (2003) Macrophages control the retention and trafficking of B lymphocytes in the splenic marginal zone.J Exp Med. 198: 333-40. 8. Taylor, P.R. et al. (2004) Development of a specific system for targeting protein to metallophilic macrophages.Proc Natl Acad Sci U S A. 101: 1963-8. 9. Alarcón, R. et al. (2005) Expression of scavenger receptors in glial cells. Comparing the adhesion of astrocytes and microglia from neonatal rats to surface-bound beta-amyloid.J Biol Chem. 280: 30406-15. 10. Anthony, R.M. et al. (2008) Identification of a receptor required for the anti-inflammatory activity of IVIG.Proc Natl Acad Sci U S A. 105: 19571-8. 11. Beamer, C.A. and Holian. A. (2008) Silica suppresses Toll-like receptor ligand-induced dendritic cell activation.FASEB J. 22: 2053-63. 12. Granucci, F. et al. (2003) The scavenger receptor MARCO mediates cytoskeleton rearrangements in dendritic cells and microglia.Blood. 102: 2940-7. 13. Mattsson, J. et al. (2011) Complement activation and complement receptors on follicular dendritic cells are critical for the function of a targeted adjuvant.J Immunol. 187: 3641-52. 14. Fukui Y et al. (2013) Effect of Lactobacillus brevis KB290 on the cell-mediated cytotoxic activity of mouse splenocytes: a DNA microarray analysis.Br J Nutr. 110 (9): 1617-29.
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