|Application ||WB, FC, IP|
|Calculated MW||46363 Da|
|Purification||Purified IgG prepared by affinity chromatography on Protein G.|
|Shelf Life||18 months from date of despatch.|
|Other Names||CD177 antigen, Human neutrophil alloantigen 2a, HNA-2a, NB1 glycoprotein, NB1 GP, Polycythemia rubra vera protein 1, PRV-1, CD177, CD177, NB1, PRV1|
|Target/Specificity||Mouse anti-Human CD177 antibody, clone MEM-166 recognizes human CD177 (neutrophil glycoprotein NB1). The neutrophil NB1 antigen is expressed by 97% of the caucasian population. Antibodies against NB1 can be involved in neonatal alloimmune neutropenia (NAN).|
|Preservative & Stabilisers||0.09% Sodium Azide|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Human CD177 Antibody, clone MEM-166 is for research use only and not for use in diagnostic or therapeutic procedures.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
1. Caruccio, L. et al. (2003) Expression of human neutrophil antigen-2a (NB1) is increased in pregnancy.Transfusion. 43 (3): 357-63. 2. Kissel, K. et al. (2002) Molecular basis of NB1 (HNA-2a, CD177) deficiency.Blood. 99 (11): 4231-3. 3. Jerke, U. et al. (2011) Complement receptor Mac-1 is an adaptor for NB1 (CD177)-mediated PR3-ANCA neutrophil activation.J Biol Chem. 286 (9): 7070-81. 4. Dillon, M. et al. (2008) Expression of the GPI-anchored receptor Prv-1 enhances thrombopoietin and IL-3-induced proliferation in hematopoietic cell lines.Leuk Res. 32: 811-9. 5. Gabillet, J. et al. (2012) Proteinase 3, the autoantigen in granulomatosis with polyangiitis, associates with calreticulin on apoptotic neutrophils, impairs macrophage phagocytosis, and promotes inflammation.J Immunol. 189: 2574-83. 6. Drewniak, A. et al. (2008) Granulocyte concentrates: prolonged functional capacity during storage in the presence of phenotypic changes.Haematologica. 93:1058-67. 7. Drewniak, A. et al. (2009) Changes in gene expression of granulocytes during in vivo granulocyte colony-stimulating factor/dexamethasone mobilization for transfusion purposes.Blood. 113: 5979-98. 8. Sachs, .U.J. et al. (2007) The neutrophil-specific antigen CD177 is a counter-receptor for platelet endothelial cell adhesion molecule-1 (CD31).J Biol Chem. 282: 23603-12.
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