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Anti-Human CD88 Antibody, clone P12/1

Mouse Anti-Human Monoclonal Antibody

  • FC - Anti-Human CD88 Antibody, clone P12/1  ABD12155
    Staining of human peripheral blood granulocytes with Mouse anti Human CD88:FITC
  • FC - Anti-Human CD88 Antibody, clone P12/1  ABD12155
    Staining of human peripheral blood granulocytes with Mouse anti Human CD88
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P21730
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype IgG2a
Clone Names P12/1
Calculated MW 39336 Da
Additional Information
Other Species Rh
Purification Purified IgG prepared by affinity chromatography on Protein G.
Immunogen C5aR - peptide: Met1 - Asn31
Shelf Life 18 months from date of despatch.
Gene ID 728
Other Names C5a anaphylatoxin chemotactic receptor 1, C5a anaphylatoxin chemotactic receptor, C5a-R, C5aR, CD88, C5AR1, C5AR, C5R1
Target/Specificity Mouse anti-Human CD88 antibody, clone P12/1 recognizes the C5a receptor (C5aR) CD88, which is predominantly expressed on cells of the myeloid lineage. Clone P12/1 was raised against a synthetic peptide comprising the N-terminal extracellular domain of the C5aR (met1-Asn31).Mouse anti-Human CD88 antibody, clone P12/1 does not inhibit the binding of C5a to its receptor.
Preservative & Stabilisers 0.09% Sodium Azide
Storage Store at +4℃ or at -20 ℃.
PrecautionsAnti-Human CD88 Antibody, clone P12/1 is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
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1. Opperman, M. et al. (1993) Probing the human receptor for C5a anaphylatoxin with site-directed antibodies. Identification of a potential ligand binding site on the NH2-terminal domain
J. Immunol. 151: 3785 - 3794. 2. Opperman, M. et al. (1995) Antibodies from the myeloid panel that react with the C5a receptor and anatagonize C5a biological activity.
In: Schlossman, S.F. (ed.) Leucocyte Typing V. O.U.P: 955-956. 3. Werfel, T. et al. (1995) Binding of anti-C5a receptor (C5aR) antibodies to cells of clinically normal human skin.
In: Schlossman, S.F. (ed.) Leucocyte Typing V. O.U.P.: 957-959. 4. Oppermann, M. (1995) Cluster report: (C5a receptor).
In: Schlossman, S.F. (ed.) Leucocyte Typing V. O.U.P. 953-954. 5. Oppermann, M. and Götze, O. (1994) Plasma clearance of the human C5a anaphylatoxin by binding to leucocyte C5a receptors
Immunology. 82: 516-521. 6. Werfel, T. et al. (1996) CD88 antibodies specifically bind to C5aR on dermal CD117+ and CD14+ cells and react with a desmosomal antigen in human skin.
J Immunol. 157: 1729-35. 7. Morris, A.C. et al. (2011) C5a-mediated neutrophil dysfunction is RhoA-dependent and predicts infection in critically ill patients.
Blood. 117: 5178-88. 8. Hüttenrauch, F. et al. (2005) G protein-coupled receptor kinases promote phosphorylation and beta-arrestin-mediated internalization of CCR5 homo- and hetero-oligomers.
J Biol Chem. 280: 37503-15. 9. Nitta, H. et al. (2013) Enhancement of human cancer cell motility and invasiveness by anaphylatoxin C5a via aberrantly expressed C5a receptor (CD88).
Clin Cancer Res. 19 (8): 2004-13. 10. Patzelt, J. et al. (2015) Expression of anaphylatoxin receptors on platelets in patients with coronary heart disease.
Atherosclerosis. 238 (2): 289-95. 11. Huber-Lang M (2005) Changes in the Novel Orphan, C5a Receptor (C5L2), during Experimental Sepsis and Sepsis in Humans
J Immunol. 174:1104-1110 12. Unnewehr H et al. (2013) Changes and regulation of the C5a receptor on neutrophils during septic shock in humans.
J Immunol. 190 (8): 4215-25. 13. Visser T et al. (2011) Isolated blunt chest injury leads to transient activation of circulating neutrophils.
Eur J Trauma Emerg Surg. 37 (2): 177-184. 14. Visser T et al. (2012) Homology in systemic neutrophil response induced by human experimental endotoxemia and by trauma.
Shock. 37 (2): 145-51. 15. Pollok-Kopp B et al. (2007) Dynamics of protein kinase C-mediated phosphorylation of the complement C5a receptor on serine 334.
J Biol Chem. 282 (7): 4345-53.

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Cat# ABD12155
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