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>   home   >   Products   >   Primary Antibodies   >   Stem Cells   >   Anti-Mouse CD49d Antibody, clone R1-2    

Anti-Mouse CD49d Antibody, clone R1-2

Rat Anti-Mouse Monoclonal Antibody

Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q00651
Reactivity Mouse
Host Rat
Clonality Monoclonal
Isotype IgG2b
Clone Names R1-2
Calculated MW 115696 Da
Additional Information
Purification Purified IgG prepared by affinity chromatography on Protein G
Immunogen Lymphoma cell line TK1.
Shelf Life 18 months from date of despatch.
Gene ID 16401
Other Names Integrin alpha-4, CD49 antigen-like family member D, Integrin alpha-IV, Lymphocyte Peyer patch adhesion molecules subunit alpha, LPAM subunit alpha, VLA-4 subunit alpha, CD49d, Itga4
Target/Specificity Rat anti-Mouse CD49d monoclonal antibody, clone R1-2 recognizes murine CD49d, an integrin, also known as integrin alpha-4 or very late antigen 4 alpha subunit. CD49d forms a heterodimer at the cell surface with CD29 to form VLA-4, and is involved in cell-cell and cell-extracellular matrix interactions.Clone R1-2 recognises an epitope within residues 195-268 of CD49d, designated as B1 (Kamadaet al.1995).Rat anti-Mouse CD49d, clone R1-2 has been reported to inhibit the adhesion of murine lymphocytes to Peyer's patch HEV, (Holzmannet al.1989)) and prevent central nervous system inflammation and experimental encephalomyelitis by inhibiting recruitment of inflammatory leukocytes (Brockeet al.1999).
Preservative & Stabilisers 0.09% Sodium Azide
Storage Store at +4℃ or at -20 ℃.
PrecautionsAnti-Mouse CD49d Antibody, clone R1-2 is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
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1. Kamata, T. et al. (1995) Identification of putative ligand-binding sites of the integrin alpha 4 beta 1 (VLA-4, CD49d/CD29)
Biochem J. 305 ( Pt 3): 945-51. 2. Holzmann, B. & Weissman, I.L. (1989) Integrin molecules involved in lymphocyte homing to Peyer's patches.
Immunol Rev. 108: 45-61. 3. Chiesa, S. et al. (2011) Mesenchymal stem cells impair in vivo T-cell priming by dendritic cells.
Proc Natl Acad Sci U S A. 108 (42): 17384-9.

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Cat# ABD12158
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