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Anti-Human CD63 Antibody, clone MEM-259

Mouse Anti-Human Monoclonal Antibody

  • FC - Anti-Human CD63 Antibody, clone MEM-259  ABD12174
    Peripheral Human Monocytes stained with Mouse anti Human CD63:APC
  • FC - Anti-Human CD63 Antibody, clone MEM-259  ABD12174
    Staining of human peripheral blood monocytes with Mouse anti Human CD63:FITC
  • FC - Anti-Human CD63 Antibody, clone MEM-259  ABD12174
    Staining of human peripheral blood monocytes with Mouse anti Human CD63
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P08962
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype IgG1
Clone Names MEM-259
Calculated MW 25637 Da
Additional Information
Purification Purified IgG prepared by affinity chromatography on Protein A
Immunogen HPB-ALL cell line.
Shelf Life 18 months from date of despatch.
Gene ID 967
Other Names CD63 antigen, Granulophysin, Lysosomal-associated membrane protein 3, LAMP-3, Melanoma-associated antigen ME491, OMA81H, Ocular melanoma-associated antigen, Tetraspanin-30, Tspan-30, CD63, CD63, MLA1, TSPAN30
Target/Specificity Mouse anti-Human CD63 antibody, clone MEM-259 recognizes the CD63 cell surface antigen, also known as granulophysin, lysozomal associated membrane protein 3 (LAMP-3), Melanoma-associated antigen ME491, Ocular melanoma-associated antigen or tetraspanin-30. CD63 is a 238 amino acid, tetraspanin glycoprotein of ~40-60 kDa.CD63 is expressed by monocytes, macrophages, endothelial cells where it is a component of Weibel-Palade bodies (Vischeret al.1993) and by a variety of cell lines. It is located intracellularly in lysosomal granules of platelets, being translocated to the surface upon activation. It may therefore by useful as a marker of platelet activation (Hamamotoet al.1994). CD63 expression is also associated with melanoma development (Radfordet al.1997) and expression is rapidly down-regulated by progesterone in endometrial tissues (Okadaet al.1999).
Preservative & Stabilisers 0.09% Sodium Azide
Storage Store at +4℃ or at -20 ℃.
PrecautionsAnti-Human CD63 Antibody, clone MEM-259 is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
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1. Casey, T.M. et al. (2007) Organelle proteomics: identification of the exocytic machinery associated with the natural killer cell secretory lysosome.
Mol Cell Proteomics. 6 (5): 767-80. 2. Durand-Panteix, S. et al. (2012) B7-H1, which represses EBV-immortalized B cell killing by autologous T and NK cells, is oppositely regulated by c-Myc and EBV latency III program at both mRNA and secretory lysosome levels.
J Immunol. 189 (1): 181-90. 3. Abdel-Latif, D. et al. (2004) Rac2 is critical for neutrophil primary granule exocytosis.
Blood. 104: 832-9. 4. Norling, L.V. et al. (2012) Resolvin D1 limits polymorphonuclear leukocyte recruitment to inflammatory loci: receptor-dependent actions.
Arterioscler Thromb Vasc Biol. 32 (8): 1970-8. 5. McKechnie, N.M. et al. (2006) Fas-ligand is stored in secretory lysosomes of ocular barrier epithelia and released with microvesicles.
Exp Eye Res. 83: 304-14. 6. Spring, F.A. et al. (2013) Tetraspanins CD81 and CD82 facilitate α4β1-mediated adhesion of human erythroblasts to vascular cell adhesion molecule-1.
PLoS One. 8(5):e62654. 7. Pliyev, B.K. (2008) Activated human neutrophils rapidly release the chemotactically active D2D3 form of the urokinase-type plasminogen activator receptor (uPAR/CD87).
Mol Cell Biochem. 321: 111-22. 8. Suraeva, N.M. et al. (2015) Changes in the Morphological and Immunological Characteristics of Mel Ibr Melanoma Cells in Response to Chicken Embryo Extract.
Bull Exp Biol Med. 159 (4): 520-3.

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Cat# ABD12174
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