|Application ||IHC-F, FC|
|Purification||Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant|
|Immunogen||CHO cells transfected with murine OX40|
|Shelf Life||18 months from date of despatch.|
|Other Names||Tumor necrosis factor receptor superfamily member 4, OX40 antigen, OX40L receptor, CD134, Tnfrsf4, Ox40, Txgp1|
|Target/Specificity||Rat anti-Mouse CD134 antibody, clone OX-86 recognizes murine OX40 (CD134), a cell surface antigen expressed only by activated T lymphocytes.Rat anti-Mouse CD134 antibody, clone OX-86 is routinely tested on concanavalin A activated mouse splenocytes.|
|Preservative & Stabilisers||0.09% Sodium Azide|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Mouse CD134 Antibody, clone OX-86 is for research use only and not for use in diagnostic or therapeutic procedures.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
1. Higgins, L. M. et al. (1999) Regulation of T Cell Activation in vitroandin vivo by targeting the OX40-OX40 ligand interaction: Amelioration of Ongoing Inflammatory Bowel Disease with an OX40-IgG Fusion Protein, but not with an OX40 ligand-IgG fusion protein.J. Immunol. 162: 486-493. 3. Lavelle, E.C. et al. (2003) Cholera toxin promotes the induction of regulatory T cells specific for bystander antigens by modulating dendritic cell activation.J Immunol. 171: 2384-92. 4. Lee, S.J. et al. (2004) 4-1BB and OX40 dual costimulation synergistically stimulate primary specific CD8 T cells for robust effector function.J Immunol. 173: 3002-12. 5. Maenz, M. et al. (2011) A comprehensive flow-cytometric analysis of graft infiltrating lymphocytes, draining lymph nodes and serum during the rejection phase in a fully allogeneic rat cornea transplant model.Mol Vis. 17: 420-9. 6. Zaini, J. et al. (2007) OX40 ligand expressed by DCs costimulates NKT and CD4+ Th cell antitumor immunity in mice.J Clin Invest. 117: 3330-8. 7. Andarini, S. et al. (2004) Adenovirus vector-mediated in vivo gene transfer of OX40 ligand to tumor cells enhances antitumor immunity of tumor-bearing hosts.Cancer Res. 64: 3281-7. 8. Malmström, V. et al. (2001) CD134L expression on dendritic cells in the mesenteric lymph nodes drives colitis in T cell-restored SCID mice.J Immunol. 166: 6972-81. 9. McHugh, R.S. et al. (2002) CD4(+)CD25(+) immunoregulatory T cells: gene expression analysis reveals a functional role for the glucocorticoid-induced TNF receptor.Immunity. 16: 311-23. 10. Thaunat, O. et al. (2010) Immune responses elicited in tertiary lymphoid tissues display distinctive features.PLoS One. 5: e11398. 11. Wythe, S.E. et al. (2012) OX40 Ligand and Programmed Cell Death 1 Ligand 2 Expression on Inflammatory Dendritic Cells Regulates CD4 T Cell Cytokine Production in the Lung during Viral DiseaseJ Immunol. 188: 1647-55.2. Takeda, K. et al. (2000) CD27-mediated activation of murine NK cells. J. Immunol. 164: 1741 - 1745.
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