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Mouse Anti-Rat Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-F, FC, IP |
|---|---|
| Primary Accession | P27471 |
| Other Accession | A4KWA1 |
| Reactivity | Rat |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgG1 |
| Clone Names | 10/78 |
| Calculated MW | 24551 Da |
| Purification | Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant |
|---|---|
| Immunogen | Purified splenic NK cells from the LEW rat strain. |
| Shelf Life | 18 months from date of despatch. |
| Gene ID | 362443 |
| Other Names | Killer cell lectin-like receptor subfamily B member 1A, NKR-P1A, Antigen 3.2.3, CD161 antigen-like family member A, Natural killer cell surface protein P1-3.2.3, NKR-P1 3.2.3, CD161a, Klrb1a, Nkrp1a |
| Target/Specificity | Mouse anti-Rat CD161 antibody, clone 10/78 recognizes the rat Killer cell lectin-like receptor subfamily B protein, also known as NKR-PI or CD161. CD161 is a 233 amino acid ~60 kDa type II single pass protein containing a single C-type lectin domain. CD161 is expressed on rat NK cells and T cell subpopulations. CD161 exists in 2 forms NKR-PIa and NKR-PIb, clone 10/78 recognizes both forms of CD161 (Liet al.2003). Clone 10/78 competes with another anti-CD161 clone, 3.2.3 for binding to antigen.Mouse anti-Rat CD161 antibody, clone 10/78 has been successfully employed for the in vivo depletion of rat NK cells in an experimental obesity model (Wrannet al.2010). |
| Preservative & Stabilisers | 0.09% Sodium Azide |
| Storage | Store at +4℃ or at -20 ℃. |
| Precautions | Anti-Rat CD161 Antibody, clone 10/78 is for research use only and not for use in diagnostic or therapeutic procedures. |
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References
1. Li, J. et al. (2003) Expression cloning and function of the rat NK activating and inhibitory receptors NKR-P1A and -P1B.Int Immunol. 15: 411-6. 2. Sedgwick, J.D. et al. (1998) Central nervous system microglial cell activation and proliferation follows direct interaction with tissue-infiltrating T cell blasts.J Immunol. 160 (11): 5320-30. 3. Schwartzkopff, J. et al. (2010) NK cell depletion delays corneal allograft rejection in baby rats.Mol Vis. 16: 1928-35. 4. Lyons, A. et al. (2011) Atorvastatin prevents age-related and amyloid-beta-induced microglial activation by blocking interferon-gamma release from natural killer cells in the brain.J Neuroinflammation. 8: 27. 5. Ali, S. et al. (2005) Combined immunostimulation and conditional cytotoxic gene therapy provide long-term survival in a large glioma model.Cancer Res. 65: 7194-204. 6. Banerjee, S. et al. (2003) Development of organised conjunctival leucocyte aggregates after corneal transplantation in rats.Br J Ophthalmol. 87: 1515-22. 7. Latta, M. et al. (2007) CXCR6 is expressed on T cells in both T helper type 1 (Th1) inflammation and allergen-induced Th2 lung inflammation but is only a weak mediator of chemotaxis.Immunology. 121: 555-64. 8. Tliba, O. et al. (2002) Evaluation of the hepatic NK cell response during the early phase of Fasciola hepatica infection in rats.Vet Res. 33 (3): 327-32. 9. Blöcher, S. et al. (2007) Acute rejection of experimental lung allografts: characterization of intravascular mononuclear leukocytes.Clin Immunol. 124 (1): 98-108. 10. Koch, M. et al. (2015) Extracellular Vesicles from MSC Modulate the Immune Response to Renal Allografts in a MHC Disparate Rat Model.Stem Cells International. 2015: 1-7. 11. Trama, A.M. et al. (2012) Lymphocyte phenotypes in wild-caught rats suggest potential mechanisms underlying increased immune sensitivity in post-industrial environments.Cell Mol Immunol. 9 (2): 163-74. 12. Wrann, C.D. et al. (2010) Obesity and NK cells affect the expression of the long form of the leptin receptor Ob-Rb in liver of F344 rats.Exp Toxicol Pathol. 62 (1): 1-8. 13. Ikezumi, Y. et al. (2000) An anti-CD5 monoclonal antibody ameliorates proteinuria and glomerular lesions in rat mesangioproliferative glomerulonephritis.Kidney Int. 58 (1): 100-14. 14. Obara, H. et al. (2005) IFN-gamma, produced by NK cells that infiltrate liver allografts early after transplantation, links the innate and adaptive immune responses.Am J Transplant. 5 (9): 2094-103. 15. Beutel, G. et al. (2013) Effect of chronic elevated asymmetric dimethylarginine (ADMA) levels on granulopoiesis.Ann Hematol. 92 (4): 505-8. 16. Lee, J.S. et al. (2011) Immunomodulatory effect of mushrooms on cytotoxic activity and cytokine production of intestinal lamina propria leukocytes does not necessarily depend on β-glucan contents.Food Chem. 126 (4): 1521-6. 17. Williamson, L.L. et al. (2015) Got worms? Perinatal exposure to helminths prevents persistent immune sensitization and cognitive dysfunction induced by early-life infection.Brain Behav Immun. pii: S0889-1591(15)00240-8. 18. Arndt, T. et al. (2014) Variable immune cell frequencies in peripheral blood of LEW.1AR1-iddm rats over time compared to other congenic LEW strains.Clin Exp Immunol. 177 (1): 168-78. 19. Kuper, C.F. et al. (2011) Oxazolone (OXA) is a respiratory allergen in Brown Norway rats.Toxicology. 290 (1): 59-68. 20. Arsenović-Ranin, N. et al. (2013) Ovarian hormone withdrawal in prepubertal developmental stage does not prevent thymic involution in rats.Exp Biol Med (Maywood). 238 (6): 641-57. 21. Djikić J et al. (2014) Age-associated changes in rat immune system: lessons learned from experimental autoimmune encephalomyelitis.Exp Gerontol. 58: 179-97. 22. Lemke Anja et al. (2015) Rat renal transplant model for mixed acute humoral and cellular rejection: Weak correlation of serum cytokines/chemokines with intragraft changesTransplant Immunology. pii: S0966-3274(15)30014-9.
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