Anti-Feline Immunodeficiency Virus p24 gag Antibody, clone PAK3-2C1
Mouse Anti-Viral Monoclonal Antibody
|Application ||WB, IHC-F, IF, FC, E|
|Purification||Purified IgG prepared by affinity chromatography on Protein A from tissue culture supernatant|
|Shelf Life||18 months from date of despatch.|
|Target/Specificity||Mouse anti-Feline Immunodeficiency Virus p24 gag antibody, clone PAK3-2C1 recognizes an immunodominant p24 epitope of feline immunodeficiency virus (FIV) p24 gag.The lentivirus FIV, responsible for a progressive and debilitating immune deficiency syndrome in domestic cats, similar to that caused by the human Immunodeficiency Virus (HIV), is a complex retrovirus with a tightly-packed genome, containing the structural genes gag, envandpro-pol and the accessory genes vif, revandORF-A/2.The specific binding epitope recognized by Mouse anti-Feline Immunodeficiency Virus p24 gag antibody, clone PAK3-2C1 appears to be enclosed in a tight peptide coil during gag production and maturation. The addition of 0.3% Triton-X detergent is recommended to reveal this epitope for antibody binding.Mouse anti-Feline Immunodeficiency Virus p24 gag antibody, clone PAK3-2C1 detects a dominant band of approximately 24kDa, and also detects p24 gag precursor bands at 36, 39, 49 and 52kDa under reducing conditions in Western blotting.Mouse anti-Feline Immunodeficiency Virus p24 gag antibody, clone PAK3-2C1 does not recognize Feline Leukaemia Virus (FeLV), Feline Herpes Virus (FHV) type 1, Feline Coronavirus or Feline Calicivirus.|
|Preservative & Stabilisers||0.09% Sodium Azide|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Feline Immunodeficiency Virus p24 gag Antibody, clone PAK3-2C1 is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
1. Lerner, D.L. et al. (1995) Increased mutation frequency of Feline Immunodeficiency Virus lacking functional deoxyuridine-triphosphatase.Proc. Natl. Acad. Sci. 92: 7480-7484. 2. Chatterji, U. et al. (2000) Feline immunodeficiency virus Vif localizes to the nucleus.J. Virol. 74: 2533-2540. 3. Norway, R. M. et al. (2001) Thymic lesions in cats infected with a pathogenic molecular clone or an ORF-A/2 -deficient molecular clone of Feline Immunodeficiency Virus.J. Virol. 75: 5833-5841. 4. Simon, J.H.M. et al. (1997) The Vif and Gag proteins of human immunodeficiency virus type 1 colocalize in infected human T cells. J. Virol. 71: 5259-5267.
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