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>   home   >   Products   >   Primary Antibodies   >   Anti-Mouse CD200R Antibody, clone OX-110 (RPE)   

Anti-Mouse CD200R Antibody, clone OX-110

Rat Anti-Mouse Monoclonal Antibody

  • FC - Anti-Mouse CD200R Antibody, clone OX-110  ABD12221
    Staining of mouse peritoneal macrophages with Rat anti Mouse CD200R
  • FC - Anti-Mouse CD200R Antibody, clone OX-110  ABD12221
    Staining of mouse peritoneal macrophages with Rat anti Mouse CD200R: FITC
  • FC - Anti-Mouse CD200R Antibody, clone OX-110  ABD12221
    Staining of mouse peritoneal macrophages with Rat anti Mouse CD200R
  • FC - Anti-Mouse CD200R Antibody, clone OX-110  ABD12221
    Staining of mouse peritoneal macrophages with Rat anti Mouse CD200R: Alexa Fluor® 488
  • FC - Anti-Mouse CD200R Antibody, clone OX-110  ABD12221
    Staining of mouse peripheral blood granulocytes with Rat anti Mouse CD200R: RPE
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9ES57
Reactivity Mouse
Host Rat
Clonality Monoclonal
Isotype IgG2a
Clone Names OX-110
Calculated MW 35505 Da
Additional Information
Purification Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
Immunogen Fusion protein mCD200RCD4d3+4
Shelf Life 18 months from date of despatch.
Gene ID 57781
Other Names Cell surface glycoprotein CD200 receptor 1, CD200 cell surface glycoprotein receptor, Cell surface glycoprotein OX2 receptor 1, Cd200r1, Mox2r, Ox2r
Target/Specificity Rat anti-Mouse CD200R antibody, clone OX-110 recognizes mouse CD200R, a cell surface glycoprotein (also known as OX2R. Mouse CD200R is a 326 amino acid, ~48 kDa single pass type I transmembrane glycoprotein, expressed primarily by peripheral blood monocytes and neutrophils but also by other leucocytes including T-lymphocytes and mast cells (Wrightet al.2003). Studies suggest that CD200-CD200R interaction may be involved in the control of myeloid cellular function (Minas and Liversidge 2006).Rat anti-Mouse CD200R antibody, clone OX-110 has been used successfully for the immunohistochemical detection of CD200R expressing cells on acetone fixed cryosections of murine synovial tissue (Simelyteet al.2008).
Preservative & Stabilisers 0.09% Sodium Azide
Storage Store at +4℃ or at -20 ℃.
PrecautionsAnti-Mouse CD200R Antibody, clone OX-110 is for research use only and not for use in diagnostic or therapeutic procedures.
Citations (0)

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1. Wright, G.J. et al. (2003) Characterization of the CD200 receptor family in mice and humans and their interactions with CD200.
J Immunol. 171 (6): 3034-46. 2. Zhao, J. et al. (2009) Evasion by stealth: inefficient immune activation underlies poor T cell response and severe disease in SARS-CoV-infected mice.
PLoS Pathog. 5 (10): e1000636. 3. Björck, P. et al. (2011) Plasmacytoid Dendritic Cell Dichotomy: Identification of IFN-{alpha} Producing Cells as a Phenotypically and Functionally Distinct Subset.
J Immunol. 186: 1477-85. 4. Dellacasa-Lindberg, I. et al. (2011) Migratory Activation of Primary Cortical Microglia upon Infection with Toxoplasma gondii.
Infect Immun. 79: 3046-52. 5. Krejsek, J. et al. (2010) Expression of CD200/CD200R regulatory molecules on granulocytes and monocytes is modulated by cardiac surgical operation.
Perfusion. 25: 389-97. 6. Rijkers, E.S. et al. (2008) The inhibitory CD200R is differentially expressed on human and mouse T and B lymphocytes.
Mol Immunol. 45: 1126-35. 7. Costello, D.A. et al. (2011) Long term potentiation is impaired in membrane glycoprotein CD200-deficient mice: a role for Toll-like receptor activation.
J Biol Chem. 286 (40): 34722-32. 8. Simelyte, E. et al. (2008) CD200-Fc, a novel antiarthritic biologic agent that targets proinflammatory cytokine expression in the joints of mice with collagen-induced arthritis.
Arthritis Rheum. 58: 1038-43. 9. Whitmore, L.C. et al. (2014) NOX2 protects against progressive lung injury and multiple organ dysfunction syndrome.
Am J Physiol Lung Cell Mol Physiol. 307: L71-82. 10. Chitnis, T. et al. (2007) Elevated neuronal expression of CD200 protects Wlds mice from inflammation-mediated neurodegeneration.
Am J Pathol. 170: 1695-712. 11. Larson, D. et al. (2012) Chronic helminth infection reduces basophil responsiveness in an IL-10-dependent manner.
J Immunol. 188: 4188-99. 12. Torrero, M.N. et al. (2009) CD200R surface expression as a marker of murine basophil activation.
Clin Exp Allergy. 39 (3): 361-9. 13. Hernangómez M et al. (2012) CD200-CD200R1 interaction contributes to neuroprotective effects of anandamide on experimentally induced inflammation.
Glia. 60 (9): 1437-50. 14. Bain, C.C. & Mowat, A.M. (2012) CD200 receptor and macrophage function in the intestine.
Immunobiology. 217 (6): 643-51. 15. Seeds, R.E. et al. (2011) The role of myeloid receptors on murine plasmacytoid dendritic cells in induction of type I interferon.
Int Immunopharmacol. 11 (7): 794-801. 16. Akkaya, M. et al. (2013) Dissection of agonistic and blocking effects of CD200 receptor antibodies.
PLoS One. 8 (5): e63325. 17. Cassard L et al. (2012) Fcγ receptors inhibit mouse and human basophil activation.
J Immunol. 189 (6): 2995-3006.

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Cat# ABD12221
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