|Application ||FC, IP|
|Clone Names||HM beta 1-1|
|Calculated MW||88231 Da|
|Purification||Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant|
|Immunogen||Purified mouse VLA-4 antigen.|
|Shelf Life||18 months from date of despatch.|
|Other Names||Integrin beta-1, Fibronectin receptor subunit beta, VLA-4 subunit beta, CD29, Itgb1|
|Target/Specificity||Hamster anti-Mouse CD29 antibody, clone HM beta 1-1 recognizes the murine integrin beta 1 subunit (CD29), a ~110 kDa cell surface glycoprotein that is widely expressed by a variety of cells including all leucocytes. CD29 forms non-covalent bonds with the integrin alpha subunits, including CD51 and CD49a-f, to form heterodimers. The ligands for these heterodimers include collagen, fibronectin, laminin and vascular adhesion molecule-1. In the immune system beta 1 integrins play an important role in cell adhesion, migration, activation and differentiation.Hamster anti-Mouse CD29 antibody, clone HM beta 1-1 is reported to inhibit beta 1 integrin mediated adhesion (Notoet al.1995).|
|Preservative & Stabilisers||0.09% Sodium Azide|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Mouse CD29 Antibody, clone HM beta 1-1 is for research use only and not for use in diagnostic or therapeutic procedures.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
1. Noto, K. et al. (1995) Identification and functional characterization of mouse CD29 with a mAb.Int Immunol. 7 (5): 835-42. 2. Lu, T.Y. et al. (2010) Epithelial cell adhesion molecule regulation is associated with the maintenance of the undifferentiated phenotype of human embryonic stem cells. J Biol Chem. 285: 8719-32. 3. Li S et al. (2010) Upregulation of CXCR4 favoring neural-like cells migration via AKT activation.Neurosci Res. 67 (4): 293-9. 5. Eto, D.S. et al. (2007) Integrin-mediated host cell invasion by type 1-piliated uropathogenic Escherichia coli.PLoS Pathog. 3: e100. 6. Tiede, B.J. et al. (2009) A novel mouse model for non-invasive single marker tracking of mammary stem cells in vivo reveals stem cell dynamics throughout pregnancy.PLoS One. 4 (11): e8035. 7. Kouros-Mehr H (2008) GATA-3 links tumor differentiation and dissemination in a luminal breast cancer model.Cancer Cell. 13: 141-52.
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