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>   home   >   Products   >   Primary Antibodies   >   Stem Cells   >   Anti-Human CD178 Antibody, clone 14C2 (RPE)   

Anti-Human CD178 Antibody, clone 14C2

Mouse Anti-Human Monoclonal Antibody

  • FC - Anti-Human CD178 Antibody, clone 14C2  ABD12259
    Staining of permeabilised Jurkat cells with Mouse anti Human CD178
  • FC - Anti-Human CD178 Antibody, clone 14C2  ABD12259
    Staining of CD178 transfected CHO cells with Mouse anti Human CD178: Alexa Fluor® 647
  • FC - Anti-Human CD178 Antibody, clone 14C2  ABD12259
    Staining of permeabilised Jurkat cells with Mouse anti Human CD178
  • FC - Anti-Human CD178 Antibody, clone 14C2  ABD12259
    Staining of permeabilised Jurkat cells with Mouse anti Human CD178:Alexa Fluor® 488
  • FC - Anti-Human CD178 Antibody, clone 14C2  ABD12259
    Staining of permeabilised Jurkat cells with Mouse anti Human CD178:RPE
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P48023
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype IgG1
Clone Names 14C2
Calculated MW 31485 Da
Additional Information
Purification Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant.
Shelf Life 18 months from date of despatch.
Gene ID 356
Other Names Tumor necrosis factor ligand superfamily member 6, Apoptosis antigen ligand, APTL, CD95 ligand, CD95-L, Fas antigen ligand, Fas ligand, FasL, CD178, Tumor necrosis factor ligand superfamily member 6, membrane form, Tumor necrosis factor ligand superfamily member 6, soluble form, Receptor-binding FasL ectodomain, Soluble Fas ligand, sFasL, ADAM10-processed FasL form, APL, FasL intracellular domain, FasL ICD, SPPL2A-processed FasL form, SPA, FASLG, APT1LG1, CD95L, FASL, TNFSF6
Target/Specificity Mouse anti-Human CD178 antibody, clone 14C2 recognizes the human CD178, also known as Tumor necrosis factor ligand superfamily member 6, Fas ligand (FasL), Apoptosis antigen ligand or CD95 ligand. CD178 is a 281 amino acid, a ~40 kDa single pass type-II transmembrane glycoprotein bearing a single intracellular FasL domain and member of the tumor necrosis factor family .CD178 is expressed by activated T lymphocytes and NK cells (Leite-de-Moraes and Dy 1997). The protein may exist as either a membrane bound or a cleaved soluble form (Garciaet al.2013). CD178 plays an important role in T cell mediated cytotoxicity (Jodoet al.2005). Binding of CD178 to Fas (CD95) results in the induction of apoptosis (Juet al.1995).Mouse anti-human CD178 antibody, clone 14C2 reported to recognize a conformation dependent non-blocking epitope on CD178 (Daburonet al.2013).
Preservative & Stabilisers 0.09% Sodium Azide
Storage Store at +4℃ or at -20 ℃.
PrecautionsAnti-Human CD178 Antibody, clone 14C2 is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
Citations (0)

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1. Legembre, P. et al. (2005) Amplification of Fas-mediated apoptosis in type II cells via microdomain recruitment.
Mol Cell Biol. 25 (15): 6811-20. 2. Mesdaghi, M. et al. (2010) Natural killer cells in allergic rhinitis patients and nonatopic controls.
Int Arch Allergy Immunol. 153 (3): 234-8. 3. Li, R. et al. (2014) Human heat shock protein-specific cytotoxic T lymphocytes display potent antitumour immunity in multiple myeloma.
Br J Haematol. 166 (5): 690-701. 4. Ouwendijk, W.J. et al. (2014) Functional characterization of ocular-derived human alphaherpesvirus cross-reactive CD4 T cells.
J Immunol. 192: 3730-9. 5. Matzner, P. et al. (2013) Resilience of the immune system in healthy young students to 30-hour sleep deprivation with psychological stress.
Neuroimmunomodulation. 20: 194-204. 6. Sullivan, E.M. et al. (2014) NK cell genotype and phenotype at diagnosis of acute lymphoblastic leukemia correlate with postinduction residual disease.
Clin Cancer Res. 20 (23): 5986-94. 7. Lindqvist CA et al. (2011) Both CD4+ FoxP3+ and CD4+ FoxP3- T cells from patients with B-cell malignancy express cytolytic markers and kill autologous leukaemic B cells in vitro.
Immunology. 133 (3): 296-306. 8. Holmannova D et al. (2015) Inhibitory CD200R and proapoptotic CD95/CD95L molecules on innate immunity cells are modulated by cardiac surgery.
Perfusion. 30 (7): 543-55.

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Cat# ABD12259
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